Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei
Zheng, Heng1,2; Chen, Qiong1,2; Zhang, Menke1; Lai, Yongji1; Lei, Liang1; Shu, Penghua1; Zhang, Jinwen2; Xue, Yongbo1; Luo, Zengwei1; Li, Yan3; Yao, Guangmin1; Zhang, Yonghui1
2013-12-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:12页码:2253-2262
摘要Fifteen new ent-kaurane diterpenoids, compounds 1-15, and two known analogues, 4-epi-henryine A (16) and leukamenin E (17), were isolated from the whole plants of Salvia cavaleriei. The structures of the new compounds were established by spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses with Cu K alpha radiation. Compounds 1-15 were evaluated for their cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480, as well as the noncancerous Beas-2B cell line. Compounds 1-10, 12, 14, and 15 showed broad-spectrum cytotoxicity, with compounds 1, 3, 6-10, 12, and 15 exhibiting more potent cytotoxicity than the positive control, cis-platin, with IC50 values ranging from 0.65 to 6.4 mu M.
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/19220
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Wuhan 430030, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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Zheng, Heng,Chen, Qiong,Zhang, Menke,et al. Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(12):2253-2262.
APA Zheng, Heng.,Chen, Qiong.,Zhang, Menke.,Lai, Yongji.,Lei, Liang.,...&Zhang, Yonghui.(2013).Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei.JOURNAL OF NATURAL PRODUCTS,76(12),2253-2262.
MLA Zheng, Heng,et al."Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei".JOURNAL OF NATURAL PRODUCTS 76.12(2013):2253-2262.
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