The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention
Luo, Cheng2,4; Wang, Kou2; Liu, Dequan3; Li, Yan2; Zhao, Qinshi2
2008-02-01
发表期刊CELLULAR & MOLECULAR IMMUNOLOGY
ISSN1672-7681
卷号5期号:1页码:1-7
摘要The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by cryo-electronic microscopy in 1980s as cavity, such as caveolae. However, the fully understanding of lipid raft was attributed by the studies of T cell activation, virus entry/budding, and other membrane events. During the interaction of T cell and antigen presenting cell, a highly organized structure is formed at the interface of the two cells, where cholesterol and sphingolipids are enriched, and form a liquid ordered phase that facilitates the signaling proteins on and off. Lipid rafts are also involved in virus entry and assembly. In this review, we will discuss cholesterol-sphingolipid floating microdomain, the lipid raft as a unique compartment of the plasma membrane, with biological functions that ensure correct intracellular traffic of proteins and lipids, such as protein-protein interactions by concentrating certain proteins in these microdomains, while excluding others. We also discuss the disruption of lipid rafts is related to different diseases and aging, and we especially exploit the lipid rafts as pharmaceutical targets for anti-virus and anti-inflammation, particularly a new approach to control HIV infection for AIDS prevention and protection by inhibition or disruption of lipid rafts.
关键词Lipid Raft Liquid Ordered Phase Liquid Crystal Phase Cholesterol Virus Assembly
学科领域Immunology
收录类别SCI
语种英语
WOS研究方向Immunology
WOS类目Immunology
WOS记录号WOS:000254276400001
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1893
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
3.Yunnam Tumor Hosp, Dept Breast Canc, Kunming 650118, Peoples R China
4.Turku Univ, Inst Biomed, FIN-20520 Turku, Finland
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Luo, Cheng,Wang, Kou,Liu, Dequan,et al. The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2008,5(1):1-7.
APA Luo, Cheng,Wang, Kou,Liu, Dequan,Li, Yan,&Zhao, Qinshi.(2008).The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention.CELLULAR & MOLECULAR IMMUNOLOGY,5(1),1-7.
MLA Luo, Cheng,et al."The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention".CELLULAR & MOLECULAR IMMUNOLOGY 5.1(2008):1-7.
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