The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention
Luo, Cheng2,4; Wang, Kou2; Liu, Dequan3; Li, Yan2; Zhao, Qinshi2
2008-02-01
Source PublicationCELLULAR & MOLECULAR IMMUNOLOGY
ISSN1672-7681
Volume5Issue:1Pages:1-7
AbstractThe first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by cryo-electronic microscopy in 1980s as cavity, such as caveolae. However, the fully understanding of lipid raft was attributed by the studies of T cell activation, virus entry/budding, and other membrane events. During the interaction of T cell and antigen presenting cell, a highly organized structure is formed at the interface of the two cells, where cholesterol and sphingolipids are enriched, and form a liquid ordered phase that facilitates the signaling proteins on and off. Lipid rafts are also involved in virus entry and assembly. In this review, we will discuss cholesterol-sphingolipid floating microdomain, the lipid raft as a unique compartment of the plasma membrane, with biological functions that ensure correct intracellular traffic of proteins and lipids, such as protein-protein interactions by concentrating certain proteins in these microdomains, while excluding others. We also discuss the disruption of lipid rafts is related to different diseases and aging, and we especially exploit the lipid rafts as pharmaceutical targets for anti-virus and anti-inflammation, particularly a new approach to control HIV infection for AIDS prevention and protection by inhibition or disruption of lipid rafts.
KeywordLipid Raft Liquid Ordered Phase Liquid Crystal Phase Cholesterol Virus Assembly
Subject AreaImmunology
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000254276400001
Citation statistics
Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1893
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
3.Yunnam Tumor Hosp, Dept Breast Canc, Kunming 650118, Peoples R China
4.Turku Univ, Inst Biomed, FIN-20520 Turku, Finland
Recommended Citation
GB/T 7714
Luo, Cheng,Wang, Kou,Liu, Dequan,et al. The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2008,5(1):1-7.
APA Luo, Cheng,Wang, Kou,Liu, Dequan,Li, Yan,&Zhao, Qinshi.(2008).The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention.CELLULAR & MOLECULAR IMMUNOLOGY,5(1),1-7.
MLA Luo, Cheng,et al."The functional roles of lipid rafts in T-Cell activation, immune diseases and HIV infection and prevention".CELLULAR & MOLECULAR IMMUNOLOGY 5.1(2008):1-7.
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