Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia
Chen, Jianchao1,3; Tian, Renrong2; Qiu, Minghua1; Lu, Lu1,3; Zheng, Yongtang2; Zhang, Zhongquan1,3
2008-02-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号69期号:4页码:1043-1048
摘要Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3 beta,7 beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3 beta,25-dihydroxy-5 beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 mu g/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50) > 200 mu g/ml), with a selectivity index more than 23.68 and 7.81, respectively. (C) 2007 Elsevier Ltd. All rights reserved.
关键词Momordica Charantia Cucurbitaceae Roots Kuguacins A-e Trinorcucurbitane Triterpenoids Anti-hiv-1
收录类别SCI ; IC
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1891
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
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Chen, Jianchao,Tian, Renrong,Qiu, Minghua,et al. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia[J]. PHYTOCHEMISTRY,2008,69(4):1043-1048.
APA Chen, Jianchao,Tian, Renrong,Qiu, Minghua,Lu, Lu,Zheng, Yongtang,&Zhang, Zhongquan.(2008).Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia.PHYTOCHEMISTRY,69(4),1043-1048.
MLA Chen, Jianchao,et al."Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia".PHYTOCHEMISTRY 69.4(2008):1043-1048.
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