Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives
Cheng, Pi1,2; Zhang, Quan1,2; Ma, Yun-Bao1; Jiang, Zhi-Yong1; Zhang, Xue-Mei1; Zhang, Feng-Xue3; Chen, Ji-Jun1
2008-07-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
卷号18期号:13页码:3787-3789
摘要A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepine were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities for the first time. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. Compound 5c showed IC(50) of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, respectively, which were 10 times higher than that of its analog 4c and led to better selective index (SI) values (SI = 23.2 and 3.4, respectively). (c) 2008 Elsevier Ltd. All rights reserved.
关键词4-aryl-6-chloro-quinolin-2-one Anti-hbv Activity 5-aryl-7-chloro-1 4-benzodiazepine
学科领域Chemistry ; Medicinal ; Chemistry ; Organic
DOI10.1016/j.bmcl.2008.05.065
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy ; Chemistry
WOS类目Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000256708000026
引用统计
被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1873
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Guangzhou Univ Tradit Chinese Med, Inst Trop Med Sci, Guangzhou, Peoples R China
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Cheng, Pi,Zhang, Quan,Ma, Yun-Bao,et al. Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(13):3787-3789.
APA Cheng, Pi.,Zhang, Quan.,Ma, Yun-Bao.,Jiang, Zhi-Yong.,Zhang, Xue-Mei.,...&Chen, Ji-Jun.(2008).Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,18(13),3787-3789.
MLA Cheng, Pi,et al."Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18.13(2008):3787-3789.
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