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题名: Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives
作者: Cheng, Pi1, 2; Zhang, Quan1, 2; Ma, Yun-Bao1; Jiang, Zhi-Yong1; Zhang, Xue-Mei1; Zhang, Feng-Xue3; null(陈纪军)1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
关键词: 4-aryl-6-chloro-quinolin-2-one ; 5-aryl-7-chloro-1,4-benzodiazepine ; anti-HBV activity
英文摘要: A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepine were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities for the first time. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. Compound 5c showed IC(50) of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, respectively, which were 10 times higher than that of its analog 4c and led to better selective index (SI) values (SI = 23.2 and 3.4, respectively). (c) 2008 Elsevier Ltd. All rights reserved.
出版日期: 2008-07-01
卷号: 18, 期号:13, 页码:3787-3789
DOI标识: 10.1016/j.bmcl.2008.05.065
语种: 英语
ISSN号: 0960-894X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1873
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Guangzhou Univ Tradit Chinese Med, Inst Trop Med Sci, Guangzhou, Peoples R China

Recommended Citation:
Cheng, P; Zhang, Q; Ma, YB; Jiang, ZY; Zhang, XM; Zhang, FX; Chen, JJ.Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloroquinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008,18(13):3787-3789
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