Zhu,RL (reprint author),E China Normal Univ,Sch Life Sci,Dept Biol,500 Dongchuan Rd,Shanghai 200241,Peoples R China.
During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxygenated bisabolane sesquiterpenoid glycoside phyllaemblicins G1-G8 (1-8) were isolated from Phyllanthus emblica, along with three known compounds, phyllaemblicin F (9), phyllaemblic acid (10) and glochicoccin D (11). Phyllaemblicin G2 (2), bearing a tricyclo [18.104.22.168] oxygen bridge ring system, is an unusual sesquiterpenoid glycoside, while phyllaemblicins G6-G8 (6-8) are dimeric sesquiterpenoid glycosides with two norbisabolane units connecting through a disaccharide. All the structures were elucidated by the extensive analysis of HRMS and NMR data. The relative configuration of phyllaemblicin G2 was constructed based on heteronuclear coupling constants measurement, and the absolute configurations for all new compounds were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. The sesquiterpenoid glycoside dimers 6-9 displayed potential anti-hepatitis B virus (HBV) activities, especially for the new compound 6 with IC50 of 8.53 +/- 0.97 and 5.68 +/- 1.75 mu M towards the HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively.
; 973 Program of Ministry of Science and Technology of P. R. China [2011CB915503]
; National Science and Technology Support Program of China [2013BAI11B02]
; Fourteenth Candidates of the Young Academic Leaders of Yunnan Province [2011CI044]
; West Light Foundation of the Chinese Academy of Sciences
; High Performance Computing Center of Kunming Institute of Botany, Chinese Academy of Sciences
1.E China Normal Univ, Sch Life Sci, Dept Biol, Shanghai 200241, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Biodivers & Biogeog East Asia, Kunming 650201, Peoples R China 3.Eszterhazy Coll, Inst Biol, Dept Bot, H-3301 Eger, Hungary 4.E China Normal Univ, Shanghai Key Lab Urban Ecol Processes & Ecorestor, Shanghai 200241, Peoples R China
Yu,Ying;Pocs,Tamas;Zhu,Rui-Liang.Notes on Early Land Plants Today. 62. A synopsis of Myriocoleopsis (Lejeuneaceae, Marchantiophyta) with special reference to transfer of Cololejeunea minutissima to Myriocoleopsis,PHYTOTAXA,2014,12(43):8764-8774