Pegaharmalines A and B, two novel beta-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala
Wang, Kai-Bo1; Yuan, Chun-Mao2; Xue, Chun-Mei1; Li, Da-Hong1; Jing, Yong-Kui3; He, Hong-Ping2; Hao, Xiao-Jiang2; Di, Ying-Tong2; Li, Zhan-Lin1; Hua, Hui-Ming1; Hua,HM (reprint author),Shenyang Pharmaceut Univ,Key Lab Struct Based Drug Design & Discovery,Minist Educ,Shenyang 110016,Peoples R China.
2014
发表期刊RSC ADVANCES
ISSN2046-2069
卷号4期号:96页码:53725-53729
产权排序第二
摘要Pegaharmalines A (1) and B (2), two novel beta-carboline alkaloids with unprecedented carbon skeletons, were isolated from the seeds of Peganum harmala. Their structures were determined by spectroscopic methods and the absolute configuration of 1 was elucidated by CD analysis. 1 and 2 exhibited significant cytotoxicities on HL-60 cells with IC50 values of 9.4 and 13.6 mu M, respectively.
关键词Liverwort Lepidolaena-clavigera Caspase-3 Inhibitory-activity Sp No 27 Absolute-configuration Aspergillus-fumigatus Tetracyclic Skeleton Chaetomium-elatum Phialophora Metabolites Acetals
学科领域Chemistry, Multidisciplinary
DOI10.1039/c4ra07985j
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000344468800043
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18484
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Hua,HM (reprint author),Shenyang Pharmaceut Univ,Key Lab Struct Based Drug Design & Discovery,Minist Educ,Shenyang 110016,Peoples R China.
作者单位1.Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
3.Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
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Wang, Kai-Bo,Yuan, Chun-Mao,Xue, Chun-Mei,et al. Pegaharmalines A and B, two novel beta-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala[J]. RSC ADVANCES,2014,4(96):53725-53729.
APA Wang, Kai-Bo.,Yuan, Chun-Mao.,Xue, Chun-Mei.,Li, Da-Hong.,Jing, Yong-Kui.,...&Hua,HM .(2014).Pegaharmalines A and B, two novel beta-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala.RSC ADVANCES,4(96),53725-53729.
MLA Wang, Kai-Bo,et al."Pegaharmalines A and B, two novel beta-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala".RSC ADVANCES 4.96(2014):53725-53729.
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