The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin
Ma, Pengcheng1; Yang, Xiangcai1,2; Kong, Qinghua1; Li, Chaocui1; Yang, Shuangjuan3; Li, Yan4; Mao, Bingyu1; Mao,BY (reprint author),Kunming Inst Zool,State Key Lab Genet Resources & Evolut,Kunming,Peoples R China.; mao@mail.kiz.ac.cn
2014-12-01
发表期刊MOLECULAR AND CELLULAR BIOLOGY
ISSN0270-7306
卷号34期号:23页码:4355-4366
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摘要Wnt/beta-catenin signaling plays critical roles in embryonic development and disease. Here, we identify RNF220, a RING domain E3 ubiquitin ligase, as a new regulator of beta-catenin. RNF220 physically interacts with beta-catenin, but instead of promoting its ubiquitination and proteasomal degradation, it stabilizes beta-catenin and promotes canonical Wnt signaling. Our analysis showed that RNF220 interacts with USP7, a ubiquitin-specific peptidase, which is required for RNF220 to stabilize beta-catenin. The RNF220/USP7 complex deubiquitinates beta-catenin and enhances canonical Wnt signaling. Interestingly, the stability of RNF220 itself is negatively regulated by Gsk3 beta, which is a key component of the beta-catenin destruction complex and is inhibited upon Wnt stimulation. Accordingly, the RNF220/USP7 complex works as a positive feedback regulator of beta-catenin signaling. In colon cancer cells with stimulated Wnt signaling, knockdown of RNF220 or USP7 impairs Wnt signaling and expression of Wnt target genes, suggesting a potentially novel role of RNF220 in Wnt-related tumorigenesis.
关键词Stem-cell Fate Shoot Apical Meristem Arabidopsis Shoot Crabs-claw Nectary Development Expression Thaliana Family Loop Polarity Iayabby2 Ad-abaxial Polarity Incarvillea Arguta Arabidopsis Thaliana
资助信息National Natural Science Foundation of China [90813004, 2009312311024]; National Natural Science Foundation of China [90813004, 2009312311024]; 973 Program [2009CB522300]; 973 Program [2009CB522300]
学科领域Biochemistry & Molecular Biology ; Cell Biology
DOI10.1128/MCB.00731-14
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Cell Biology
WOS记录号WOS:000344631500011
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18482
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Mao,BY (reprint author),Kunming Inst Zool,State Key Lab Genet Resources & Evolut,Kunming,Peoples R China.; mao@mail.kiz.ac.cn
作者单位1.Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Peoples R China
3.Kunming Inst Zool, Kunming Biol Divers Reg Ctr Large Apparat & Equip, Kunming, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China
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Ma, Pengcheng,Yang, Xiangcai,Kong, Qinghua,et al. The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin[J]. MOLECULAR AND CELLULAR BIOLOGY,2014,34(23):4355-4366.
APA Ma, Pengcheng.,Yang, Xiangcai.,Kong, Qinghua.,Li, Chaocui.,Yang, Shuangjuan.,...&mao@mail.kiz.ac.cn.(2014).The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin.MOLECULAR AND CELLULAR BIOLOGY,34(23),4355-4366.
MLA Ma, Pengcheng,et al."The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin".MOLECULAR AND CELLULAR BIOLOGY 34.23(2014):4355-4366.
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