| The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin | |
Ma, Pengcheng1; Yang, Xiangcai1,2; Kong, Qinghua1; Li, Chaocui1; Yang, Shuangjuan3; Li, Yan4 ; Mao, Bingyu1; Mao,BY (reprint author),Kunming Inst Zool,State Key Lab Genet Resources & Evolut,Kunming,Peoples R China.; mao@mail.kiz.ac.cn
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| 2014-12-01 | |
| 发表期刊 | MOLECULAR AND CELLULAR BIOLOGY
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| ISSN | 0270-7306 |
| 卷号 | 34期号:23页码:4355-4366 |
| 摘要 | Wnt/beta-catenin signaling plays critical roles in embryonic development and disease. Here, we identify RNF220, a RING domain E3 ubiquitin ligase, as a new regulator of beta-catenin. RNF220 physically interacts with beta-catenin, but instead of promoting its ubiquitination and proteasomal degradation, it stabilizes beta-catenin and promotes canonical Wnt signaling. Our analysis showed that RNF220 interacts with USP7, a ubiquitin-specific peptidase, which is required for RNF220 to stabilize beta-catenin. The RNF220/USP7 complex deubiquitinates beta-catenin and enhances canonical Wnt signaling. Interestingly, the stability of RNF220 itself is negatively regulated by Gsk3 beta, which is a key component of the beta-catenin destruction complex and is inhibited upon Wnt stimulation. Accordingly, the RNF220/USP7 complex works as a positive feedback regulator of beta-catenin signaling. In colon cancer cells with stimulated Wnt signaling, knockdown of RNF220 or USP7 impairs Wnt signaling and expression of Wnt target genes, suggesting a potentially novel role of RNF220 in Wnt-related tumorigenesis. |
| 关键词 | Stem-cell Fate Shoot Apical Meristem Arabidopsis Shoot Crabs-claw Nectary Development Expression Thaliana Family Loop Polarity Iayabby2 Ad-abaxial Polarity Incarvillea Arguta Arabidopsis Thaliana |
| 学科领域 | Biochemistry & Molecular Biology ; Cell Biology |
| DOI | 10.1128/MCB.00731-14 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344631500011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18482 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Mao,BY (reprint author),Kunming Inst Zool,State Key Lab Genet Resources & Evolut,Kunming,Peoples R China.; mao@mail.kiz.ac.cn |
| 作者单位 | 1.Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Peoples R China 3.Kunming Inst Zool, Kunming Biol Divers Reg Ctr Large Apparat & Equip, Kunming, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Pengcheng,Yang, Xiangcai,Kong, Qinghua,et al. The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin[J]. MOLECULAR AND CELLULAR BIOLOGY,2014,34(23):4355-4366. |
| APA | Ma, Pengcheng.,Yang, Xiangcai.,Kong, Qinghua.,Li, Chaocui.,Yang, Shuangjuan.,...&mao@mail.kiz.ac.cn.(2014).The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin.MOLECULAR AND CELLULAR BIOLOGY,34(23),4355-4366. |
| MLA | Ma, Pengcheng,et al."The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin".MOLECULAR AND CELLULAR BIOLOGY 34.23(2014):4355-4366. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| MCB.00731-14.full.pd（1708KB） | 开放获取 | CC BY-NC-ND | 浏览 请求全文 | |||
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