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题名: The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin
作者: Ma, Pengcheng1; Yang, Xiangcai1, 2; Kong, Qinghua1; Li, Chaocui1; Yang, Shuangjuan3; null(李艳)4; Mao, Bingyu1
刊名: MOLECULAR AND CELLULAR BIOLOGY
出版日期: 2014-12-01
卷号: 34, 期号:23, 页码:4355-4366
关键词: STEM-CELL FATE ; SHOOT APICAL MERISTEM ; ARABIDOPSIS SHOOT ; CRABS-CLAW ; NECTARY DEVELOPMENT ; EXPRESSION ; THALIANA ; FAMILY ; LOOP ; POLARITY ; IaYABBY2 ; Ad-abaxial polarity ; Incarvillea arguta ; Arabidopsis thaliana
学科分类: Biochemistry & Molecular Biology;Cell Biology
DOI: 10.1128/MCB.00731-14
通讯作者: Mao,BY (reprint author),Kunming Inst Zool,State Key Lab Genet Resources & Evolut,Kunming,Peoples R China. ; mao@mail.kiz.ac.cn
文章类型: Article
英文摘要: Wnt/beta-catenin signaling plays critical roles in embryonic development and disease. Here, we identify RNF220, a RING domain E3 ubiquitin ligase, as a new regulator of beta-catenin. RNF220 physically interacts with beta-catenin, but instead of promoting its ubiquitination and proteasomal degradation, it stabilizes beta-catenin and promotes canonical Wnt signaling. Our analysis showed that RNF220 interacts with USP7, a ubiquitin-specific peptidase, which is required for RNF220 to stabilize beta-catenin. The RNF220/USP7 complex deubiquitinates beta-catenin and enhances canonical Wnt signaling. Interestingly, the stability of RNF220 itself is negatively regulated by Gsk3 beta, which is a key component of the beta-catenin destruction complex and is inhibited upon Wnt stimulation. Accordingly, the RNF220/USP7 complex works as a positive feedback regulator of beta-catenin signaling. In colon cancer cells with stimulated Wnt signaling, knockdown of RNF220 or USP7 impairs Wnt signaling and expression of Wnt target genes, suggesting a potentially novel role of RNF220 in Wnt-related tumorigenesis.
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: NEGATIVE REGULATOR ; XENOPUS EMBRYOS ; C-CBL ; PATHWAY ; PROTEIN ; P53 ; KINASE ; DEGRADATION ; DISEASE ; MECHANISMS
收录类别: SCI
项目资助者: National Natural Science Foundation of China [90813004, 2009312311024] ; 973 Program [2009CB522300]
语种: 英语
WOS记录号: WOS:000344631500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18482
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Peoples R China
3.Kunming Inst Zool, Kunming Biol Divers Reg Ctr Large Apparat & Equip, Kunming, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China

Recommended Citation:
Ma,Pengcheng;Yang,Xiangcai;Kong,Qinghua;Li,Chaocui;Yang,Shuangjuan;Li,Yan;Mao,Bingyu.The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of beta-Catenin,MOLECULAR AND CELLULAR BIOLOGY,2014,97(11):1481-1486
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