| Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer | |
O'Leary, Patrick C.1; Terrile, Marta1; Bajor, Malgorzata2; Gaj, Pawel2; Hennessy, Bryan T.3,4; Mills, Gordon B.4; Zagozdzon, Agnieszka1; O'Connor, Darran P.1; Brennan, Donal J.1; Connor, Kate1; Li, Jane4; Gonzalez-Angulo, Ana Maria5; Sun, Han-Dong6 ; Pu, Jian-Xin6; Ponten, Fredrik7; Uhlen, Mathias8; Jirstrom, Karin9; Nowis, Dominika A.2,10; Crown, John P.11; Zagozdzon, Radoslaw1,2; Gallagher, William M.1; Zagozdzon,R (reprint author),UCD Sch Biomol & Biomed Sci,UCD Conway Inst,Canc Biol & Therapeut Lab,Dublin 4,Ireland.; radoslaw.zagozdzon@wum.edu.pl; william.gallagher@ucd.ie
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| 2014 | |
| 发表期刊 | BREAST CANCER RESEARCH
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| ISSN | 1465-542X |
| 卷号 | 16期号:4页码:8220-8224 |
| 摘要 | Introduction: Peroxiredoxin-1 (PRDX1) is a multifunctional protein, acting as a hydrogen peroxide (H2O2) scavenger, molecular chaperone and immune modulator. Although differential PRDX1 expression has been described in many tumors, the potential role of PRDX1 in breast cancer remains highly ambiguous. Using a comprehensive antibody-based proteomics approach, we interrogated PRDX1 protein as a putative biomarker in estrogen receptor (ER)-positive breast cancer. |
| 关键词 | Natural-products Roots Secretion Norsesquiterpenoids Norbisabolane Pyrimidine |
| 学科领域 | Oncology |
| DOI | 10.1186/bcr3691 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344310300011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18479 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Zagozdzon,R (reprint author),UCD Sch Biomol & Biomed Sci,UCD Conway Inst,Canc Biol & Therapeut Lab,Dublin 4,Ireland.; radoslaw.zagozdzon@wum.edu.pl; william.gallagher@ucd.ie |
| 作者单位 | 1.UCD Sch Biomol & Biomed Sci, UCD Conway Inst, Canc Biol & Therapeut Lab, Dublin 4, Ireland 2.Med Univ Warsaw, Ctr Biostruct Res, Dept Immunol, PL-02097 Warsaw, Poland 3.Royal Coll Surgeons Ireland, Beaumont Hosp, Dept Med Oncol, Dublin 2, Ireland 4.Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77054 USA 5.Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77054 USA 6.Chinese Acad Sci, Kunming Bot Garden, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan 650204, Peoples R China 7.Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden 8.Royal Inst Technol, AlbaNova Univ Ctr, S-10044 Stockholm, Sweden 9.Lund Univ, Skane Univ Hosp, Dept Clin Sci, Div Pathol, S-22185 Lund, Sweden 10.Med Univ Warsaw, Dept Gen Transplant & Liver Surg, PL-02097 Warsaw, Poland 11.Dublin City Univ, Natl Inst Cellular Biotechnol, Dublin 9, Ireland |
| 推荐引用方式 GB/T 7714 | O'Leary, Patrick C.,Terrile, Marta,Bajor, Malgorzata,et al. Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer[J]. BREAST CANCER RESEARCH,2014,16(4):8220-8224. |
| APA | O'Leary, Patrick C..,Terrile, Marta.,Bajor, Malgorzata.,Gaj, Pawel.,Hennessy, Bryan T..,...&william.gallagher@ucd.ie.(2014).Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.BREAST CANCER RESEARCH,16(4),8220-8224. |
| MLA | O'Leary, Patrick C.,et al."Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer".BREAST CANCER RESEARCH 16.4(2014):8220-8224. |
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