Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer
O'Leary, Patrick C.1; Terrile, Marta1; Bajor, Malgorzata2; Gaj, Pawel2; Hennessy, Bryan T.3,4; Mills, Gordon B.4; Zagozdzon, Agnieszka1; O'Connor, Darran P.1; Brennan, Donal J.1; Connor, Kate1; Li, Jane4; Gonzalez-Angulo, Ana Maria5; Sun, Han-Dong6; Pu, Jian-Xin6; Ponten, Fredrik7; Uhlen, Mathias8; Jirstrom, Karin9; Nowis, Dominika A.2,10; Crown, John P.11; Zagozdzon, Radoslaw1,2; Gallagher, William M.1; Zagozdzon,R (reprint author),UCD Sch Biomol & Biomed Sci,UCD Conway Inst,Canc Biol & Therapeut Lab,Dublin 4,Ireland.; radoslaw.zagozdzon@wum.edu.pl; william.gallagher@ucd.ie
2014
发表期刊BREAST CANCER RESEARCH
ISSN1465-542X
卷号16期号:4页码:8220-8224
产权排序第二
摘要Introduction: Peroxiredoxin-1 (PRDX1) is a multifunctional protein, acting as a hydrogen peroxide (H2O2) scavenger, molecular chaperone and immune modulator. Although differential PRDX1 expression has been described in many tumors, the potential role of PRDX1 in breast cancer remains highly ambiguous. Using a comprehensive antibody-based proteomics approach, we interrogated PRDX1 protein as a putative biomarker in estrogen receptor (ER)-positive breast cancer.
关键词Natural-products Roots Secretion Norsesquiterpenoids Norbisabolane Pyrimidine
资助信息Science and Technology Projects of Yunnan Province [2009CD078]; Science and Technology Projects of Yunnan Province [2009CD078]; Science Foundation of Yunnan Education Bureau; Science Foundation of Yunnan Education Bureau
学科领域Oncology
DOI10.1186/bcr3691
收录类别SCI
语种英语
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000344310300011
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18479
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Zagozdzon,R (reprint author),UCD Sch Biomol & Biomed Sci,UCD Conway Inst,Canc Biol & Therapeut Lab,Dublin 4,Ireland.; radoslaw.zagozdzon@wum.edu.pl; william.gallagher@ucd.ie
作者单位1.UCD Sch Biomol & Biomed Sci, UCD Conway Inst, Canc Biol & Therapeut Lab, Dublin 4, Ireland
2.Med Univ Warsaw, Ctr Biostruct Res, Dept Immunol, PL-02097 Warsaw, Poland
3.Royal Coll Surgeons Ireland, Beaumont Hosp, Dept Med Oncol, Dublin 2, Ireland
4.Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77054 USA
5.Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77054 USA
6.Chinese Acad Sci, Kunming Bot Garden, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan 650204, Peoples R China
7.Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden
8.Royal Inst Technol, AlbaNova Univ Ctr, S-10044 Stockholm, Sweden
9.Lund Univ, Skane Univ Hosp, Dept Clin Sci, Div Pathol, S-22185 Lund, Sweden
10.Med Univ Warsaw, Dept Gen Transplant & Liver Surg, PL-02097 Warsaw, Poland
11.Dublin City Univ, Natl Inst Cellular Biotechnol, Dublin 9, Ireland
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O'Leary, Patrick C.,Terrile, Marta,Bajor, Malgorzata,et al. Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer[J]. BREAST CANCER RESEARCH,2014,16(4):8220-8224.
APA O'Leary, Patrick C..,Terrile, Marta.,Bajor, Malgorzata.,Gaj, Pawel.,Hennessy, Bryan T..,...&william.gallagher@ucd.ie.(2014).Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.BREAST CANCER RESEARCH,16(4),8220-8224.
MLA O'Leary, Patrick C.,et al."Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer".BREAST CANCER RESEARCH 16.4(2014):8220-8224.
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