Introduction: Peroxiredoxin-1 (PRDX1) is a multifunctional protein, acting as a hydrogen peroxide (H2O2) scavenger, molecular chaperone and immune modulator. Although differential PRDX1 expression has been described in many tumors, the potential role of PRDX1 in breast cancer remains highly ambiguous. Using a comprehensive antibody-based proteomics approach, we interrogated PRDX1 protein as a putative biomarker in estrogen receptor (ER)-positive breast cancer.
1.UCD Sch Biomol & Biomed Sci, UCD Conway Inst, Canc Biol & Therapeut Lab, Dublin 4, Ireland 2.Med Univ Warsaw, Ctr Biostruct Res, Dept Immunol, PL-02097 Warsaw, Poland 3.Royal Coll Surgeons Ireland, Beaumont Hosp, Dept Med Oncol, Dublin 2, Ireland 4.Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77054 USA 5.Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77054 USA 6.Chinese Acad Sci, Kunming Bot Garden, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan 650204, Peoples R China 7.Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden 8.Royal Inst Technol, AlbaNova Univ Ctr, S-10044 Stockholm, Sweden 9.Lund Univ, Skane Univ Hosp, Dept Clin Sci, Div Pathol, S-22185 Lund, Sweden 10.Med Univ Warsaw, Dept Gen Transplant & Liver Surg, PL-02097 Warsaw, Poland 11.Dublin City Univ, Natl Inst Cellular Biotechnol, Dublin 9, Ireland
O'Leary,Patrick C.;Terrile,Marta;Bajor,Malgorzata;Gaj,Pawel;Hennessy,Bryan T.;Mills,Gordon B.;Zagozdzon,Agnieszka;O'Connor,Darran P.;Brennan,Donal J.;Connor,Kate;Li,Jane;Gonzalez-Angulo,Ana Maria;Sun,Han-Dong;Pu,Jian-Xin;Ponten,Fredrik;Uhlen,Mathias;Jirstrom,Karin;Nowis,Dominika A.;Crown,John P.;Zagozdzon,Radoslaw;Gallagher,William M..Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer,BREAST CANCER RESEARCH,2014,13(4):8220-8224