| Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities | |
Dou, Man1,3; Di, Lei1; Zhou, Li-Li2; Yan, Yong-Ming1,4; Wang, Xin-Long1; Zhou, Feng-Jiao1; Yang, Zhu-Liang5 ; Li, Rong-Tao3; Hou, Fan-Fan2; Cheng, Yong-Xian1; Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China.; lrt512@163.com; ffhouguangzhou@163.com; yxcheng@mail.kib.ac.cn
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| 2014-12-05 | |
| 发表期刊 | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| 卷号 | 16期号:23页码:6064-6067 |
| 摘要 | (+)- and (-)-cochlearols A (1) and B (2), two meroterpenoids with novel polycyclic skeletons, were isolated from the fruiting bodies of the fungus Ganoderma cochlear. Their structures and stereochemistry were determined by using spectroscopic, computational and single-crystal X-ray diffraction methods. Cochlearol A is a new normeroterpenoid containing a naturally unusual dioxaspiro[4.5]decane motif. Biological studies showed that (-)-2 is a strong inhibitor of p-Smads, exhibiting renoprotective activities in TGF-beta 1 induced rat renal proximal tubular cells. |
| 关键词 | Thermal Time Requirements Environmental-factors Emergence Steppe Light Ecology Desert China Plant Germinability Alpine Steppe Seed Germination Cardinal Temperature Thermal Time Stipa Species Tibetan Plateau |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/ol502806j |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000346037500007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18475 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China.; lrt512@163.com; ffhouguangzhou@163.com; yxcheng@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China 3.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dou, Man,Di, Lei,Zhou, Li-Li,et al. Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities[J]. ORGANIC LETTERS,2014,16(23):6064-6067. |
| APA | Dou, Man.,Di, Lei.,Zhou, Li-Li.,Yan, Yong-Ming.,Wang, Xin-Long.,...&yxcheng@mail.kib.ac.cn.(2014).Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities.ORGANIC LETTERS,16(23),6064-6067. |
| MLA | Dou, Man,et al."Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities".ORGANIC LETTERS 16.23(2014):6064-6067. |
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