Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities
Dou, Man1,3; Di, Lei1; Zhou, Li-Li2; Yan, Yong-Ming1,4; Wang, Xin-Long1; Zhou, Feng-Jiao1; Yang, Zhu-Liang5; Li, Rong-Tao3; Hou, Fan-Fan2; Cheng, Yong-Xian1; Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China.; lrt512@163.com; ffhouguangzhou@163.com; yxcheng@mail.kib.ac.cn
2014-12-05
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号16期号:23页码:6064-6067
摘要(+)- and (-)-cochlearols A (1) and B (2), two meroterpenoids with novel polycyclic skeletons, were isolated from the fruiting bodies of the fungus Ganoderma cochlear. Their structures and stereochemistry were determined by using spectroscopic, computational and single-crystal X-ray diffraction methods. Cochlearol A is a new normeroterpenoid containing a naturally unusual dioxaspiro[4.5]decane motif. Biological studies showed that (-)-2 is a strong inhibitor of p-Smads, exhibiting renoprotective activities in TGF-beta 1 induced rat renal proximal tubular cells.
关键词Thermal Time Requirements Environmental-factors Emergence Steppe Light Ecology Desert China Plant Germinability Alpine Steppe Seed Germination Cardinal Temperature Thermal Time Stipa Species Tibetan Plateau
学科领域Chemistry, Organic
DOI10.1021/ol502806j
收录类别SCI ; IC
语种英语
WOS记录号WOS:000346037500007
引用统计
被引频次:80[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18475
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China.; lrt512@163.com; ffhouguangzhou@163.com; yxcheng@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China
3.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China
推荐引用方式
GB/T 7714
Dou, Man,Di, Lei,Zhou, Li-Li,et al. Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities[J]. ORGANIC LETTERS,2014,16(23):6064-6067.
APA Dou, Man.,Di, Lei.,Zhou, Li-Li.,Yan, Yong-Ming.,Wang, Xin-Long.,...&yxcheng@mail.kib.ac.cn.(2014).Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities.ORGANIC LETTERS,16(23),6064-6067.
MLA Dou, Man,et al."Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities".ORGANIC LETTERS 16.23(2014):6064-6067.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Dou-2014-Cochlearols(299KB) 开放获取CC BY-NC-ND浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Dou, Man]的文章
[Di, Lei]的文章
[Zhou, Li-Li]的文章
百度学术
百度学术中相似的文章
[Dou, Man]的文章
[Di, Lei]的文章
[Zhou, Li-Li]的文章
必应学术
必应学术中相似的文章
[Dou, Man]的文章
[Di, Lei]的文章
[Zhou, Li-Li]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Dou-2014-Cochlearols A and B, Polycyclic Merot.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。