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题名: Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities
作者: Dou, Man1, 3; Di, Lei1; Zhou, Li-Li2; Yan, Yong-Ming1, 4; Wang, Xin-Long1; Zhou, Feng-Jiao1; null(杨祝良)5; Li, Rong-Tao3; Hou, Fan-Fan2; Cheng, Yong-Xian1
刊名: ORGANIC LETTERS
出版日期: 2014-12-05
卷号: 16, 期号:23, 页码:6064-6067
关键词: THERMAL TIME REQUIREMENTS ; ENVIRONMENTAL-FACTORS ; EMERGENCE ; STEPPE ; LIGHT ; ECOLOGY ; DESERT ; CHINA ; PLANT ; GERMINABILITY ; alpine steppe ; seed germination ; cardinal temperature ; thermal time ; Stipa species ; Tibetan Plateau
学科分类: Chemistry, Organic
DOI: 10.1021/ol502806j
通讯作者: Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China. ; lrt512@163.com ; ffhouguangzhou@163.com ; yxcheng@mail.kib.ac.cn
文章类型: Article
英文摘要: (+)- and (-)-cochlearols A (1) and B (2), two meroterpenoids with novel polycyclic skeletons, were isolated from the fruiting bodies of the fungus Ganoderma cochlear. Their structures and stereochemistry were determined by using spectroscopic, computational and single-crystal X-ray diffraction methods. Cochlearol A is a new normeroterpenoid containing a naturally unusual dioxaspiro[4.5]decane motif. Biological studies showed that (-)-2 is a strong inhibitor of p-Smads, exhibiting renoprotective activities in TGF-beta 1 induced rat renal proximal tubular cells.
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
收录类别: SCI ; IC
项目资助者: Funds for International Cooperation and Exchange of the National Natural Science Foundation of China [31210103919] ; National Basic Research Program of China [2014CB138305] ; CAS/SAFEA International Partnership Program for Creative Research Teams
语种: 英语
WOS记录号: WOS:000346037500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18475
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China
3.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China

Recommended Citation:
Dou,Man;Di,Lei;Zhou,Li-Li;Yan,Yong-Ming;Wang,Xin-Long;Zhou,Feng-Jiao;Yang,Zhu-Liang;Li,Rong-Tao;Hou,Fan-Fan;Cheng,Yong-Xian.Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities,ORGANIC LETTERS,2014,69(1):93-115
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文件名: Dou-2014-Cochlearols A and B, Polycyclic Merot.pdf
格式: Adobe PDF
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