Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China.
(+)- and (-)-cochlearols A (1) and B (2), two meroterpenoids with novel polycyclic skeletons, were isolated from the fruiting bodies of the fungus Ganoderma cochlear. Their structures and stereochemistry were determined by using spectroscopic, computational and single-crystal X-ray diffraction methods. Cochlearol A is a new normeroterpenoid containing a naturally unusual dioxaspiro[4.5]decane motif. Biological studies showed that (-)-2 is a strong inhibitor of p-Smads, exhibiting renoprotective activities in TGF-beta 1 induced rat renal proximal tubular cells.
Funds for International Cooperation and Exchange of the National Natural Science Foundation of China 
; National Basic Research Program of China [2014CB138305]
; CAS/SAFEA International Partnership Program for Creative Research Teams
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China 3.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China
Dou,Man;Di,Lei;Zhou,Li-Li;Yan,Yong-Ming;Wang,Xin-Long;Zhou,Feng-Jiao;Yang,Zhu-Liang;Li,Rong-Tao;Hou,Fan-Fan;Cheng,Yong-Xian.Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities,ORGANIC LETTERS,2014,69(1):93-115