Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities
Dou, Man1,3; Di, Lei1; Zhou, Li-Li2; Yan, Yong-Ming1,4; Wang, Xin-Long1; Zhou, Feng-Jiao1; Yang, Zhu-Liang5; Li, Rong-Tao3; Hou, Fan-Fan2; Cheng, Yong-Xian1; Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China.; lrt512@163.com; ffhouguangzhou@163.com; yxcheng@mail.kib.ac.cn
2014-12-05
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号16期号:23页码:6064-6067
产权排序第一
摘要(+)- and (-)-cochlearols A (1) and B (2), two meroterpenoids with novel polycyclic skeletons, were isolated from the fruiting bodies of the fungus Ganoderma cochlear. Their structures and stereochemistry were determined by using spectroscopic, computational and single-crystal X-ray diffraction methods. Cochlearol A is a new normeroterpenoid containing a naturally unusual dioxaspiro[4.5]decane motif. Biological studies showed that (-)-2 is a strong inhibitor of p-Smads, exhibiting renoprotective activities in TGF-beta 1 induced rat renal proximal tubular cells.
关键词Thermal Time Requirements Environmental-factors Emergence Steppe Light Ecology Desert China Plant Germinability Alpine Steppe Seed Germination Cardinal Temperature Thermal Time Stipa Species Tibetan Plateau
资助信息Funds for International Cooperation and Exchange of the National Natural Science Foundation of China [31210103919]; Funds for International Cooperation and Exchange of the National Natural Science Foundation of China [31210103919]; National Basic Research Program of China [2014CB138305]; CAS/SAFEA International Partnership Program for Creative Research Teams; National Basic Research Program of China [2014CB138305]; CAS/SAFEA International Partnership Program for Creative Research Teams
学科领域Chemistry, Organic
DOI10.1021/ol502806j
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000346037500007
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18475
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li,RT (reprint author),Kunming Univ Sci Technol,Fac Life Sci & Technol,Kunming 650500,Peoples R China.; lrt512@163.com; ffhouguangzhou@163.com; yxcheng@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Div Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China
3.Kunming Univ Sci Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Peoples R China
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GB/T 7714
Dou, Man,Di, Lei,Zhou, Li-Li,et al. Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities[J]. ORGANIC LETTERS,2014,16(23):6064-6067.
APA Dou, Man.,Di, Lei.,Zhou, Li-Li.,Yan, Yong-Ming.,Wang, Xin-Long.,...&yxcheng@mail.kib.ac.cn.(2014).Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities.ORGANIC LETTERS,16(23),6064-6067.
MLA Dou, Man,et al."Cochlearols A and B, Polycyclic Meroterpenoids from the Fungus Ganoderma cochlear That Have Renoprotective Activities".ORGANIC LETTERS 16.23(2014):6064-6067.
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