Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A

doi:10.1002/ejoc.201403145

	Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A
	Fang, Lijing 1; Wu, Chunlei 1; Yu, Zaidan 1; Shang, Peng 1; Cheng, Yongxian 2; Peng, Yuefeng 1; Su, Wu 1; Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov ; wu.su@siat.ac.cn
	2014-12-01
发表期刊	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN	1434-193X
卷号	67 期号:34 页码:7572-7576
摘要	A reproducible, highly efficient, and racemization-free protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids was developed. The efficiency of the reaction was demonstrated by the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. This protocol will broaden the application of triphosgene in the synthesis of a wide range of peptides, including aromatic amino acids, N-alkylated amino acids, as well as proteinogenic amino acids.
关键词	Synthetic Methods Solid-phase Synthesis Amidation Peptides Total Synthesis
学科领域	Chemistry, Organic
DOI	10.1002/ejoc.201403145
收录类别	SCI
语种	英语
WOS记录号	WOS:000345506700007
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18474
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn
作者单位	1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Fang, Lijing,Wu, Chunlei,Yu, Zaidan,et al. Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014,67(34):7572-7576.
APA	Fang, Lijing.,Wu, Chunlei.,Yu, Zaidan.,Shang, Peng.,Cheng, Yongxian.,...&wu.su@siat.ac.cn.(2014).Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,67(34),7572-7576.
MLA	Fang, Lijing,et al."Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 67.34(2014):7572-7576.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Fang-2014-Triphosgen（271KB）			开放获取	CC BY-NC-ND	浏览下载