| Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A | |
| Fang, Lijing1; Wu, Chunlei1; Yu, Zaidan1; Shang, Peng1; Cheng, Yongxian2; Peng, Yuefeng1; Su, Wu1; Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn | |
| 2014-12-01 | |
| 发表期刊 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| ISSN | 1434-193X |
| 卷号 | 67期号:34页码:7572-7576 |
| 摘要 | A reproducible, highly efficient, and racemization-free protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids was developed. The efficiency of the reaction was demonstrated by the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. This protocol will broaden the application of triphosgene in the synthesis of a wide range of peptides, including aromatic amino acids, N-alkylated amino acids, as well as proteinogenic amino acids. |
| 关键词 | Synthetic Methods Solid-phase Synthesis Amidation Peptides Total Synthesis |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1002/ejoc.201403145 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345506700007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18474 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Lijing,Wu, Chunlei,Yu, Zaidan,et al. Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014,67(34):7572-7576. |
| APA | Fang, Lijing.,Wu, Chunlei.,Yu, Zaidan.,Shang, Peng.,Cheng, Yongxian.,...&wu.su@siat.ac.cn.(2014).Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,67(34),7572-7576. |
| MLA | Fang, Lijing,et al."Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 67.34(2014):7572-7576. |
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| Fang-2014-Triphosgen（271KB） | 开放获取 | CC BY-NC-ND | 浏览 下载 | |||
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