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题名: Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A
作者: Fang, Lijing1; Wu, Chunlei1; Yu, Zaidan1; Shang, Peng1; null(程永现)2; Peng, Yuefeng1; Su, Wu1
刊名: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
出版日期: 2014-12-01
卷号: 67, 期号:34, 页码:7572-7576
关键词: Synthetic methods ; Solid-phase synthesis ; Amidation ; Peptides ; Total synthesis
学科分类: Chemistry, Organic
DOI: 10.1002/ejoc.201403145
通讯作者: Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China. ; yuefeng.peng@fda.hhs.gov ; wu.su@siat.ac.cn
文章类型: Article
英文摘要: A reproducible, highly efficient, and racemization-free protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids was developed. The efficiency of the reaction was demonstrated by the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. This protocol will broaden the application of triphosgene in the synthesis of a wide range of peptides, including aromatic amino acids, N-alkylated amino acids, as well as proteinogenic amino acids.
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: AMIDE BOND FORMATION ; IN-SITU GENERATION ; DIABETIC-NEPHROPATHY ; CHEMICAL-SYNTHESIS ; PEPTIDE-SYNTHESIS ; ORGANIC-SYNTHESIS ; AMINO-ACIDS ; REAGENTS ; CALYCINUM ; INFLAMMATION
收录类别: SCI
项目资助者: Independent Research Program of the Chinese Academy of Sciences [KSCX2-EW-J-24] ; National Natural Science Foundation of China [31270273, 31070192, 30770167] ; Basic Research Program from the Ministry of Science and Technology of China [2007FY110100]
语种: 英语
WOS记录号: WOS:000345506700007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18474
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China

Recommended Citation:
Fang,Lijing;Wu,Chunlei;Yu,Zaidan;Shang,Peng;Cheng,Yongxian;Peng,Yuefeng;Su,Wu.Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A,EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014,67(3):238-249
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