Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A
Fang, Lijing1; Wu, Chunlei1; Yu, Zaidan1; Shang, Peng1; Cheng, Yongxian2; Peng, Yuefeng1; Su, Wu1; Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn
2014-12-01
发表期刊EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN1434-193X
卷号67期号:34页码:7572-7576
产权排序第三
摘要A reproducible, highly efficient, and racemization-free protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids was developed. The efficiency of the reaction was demonstrated by the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. This protocol will broaden the application of triphosgene in the synthesis of a wide range of peptides, including aromatic amino acids, N-alkylated amino acids, as well as proteinogenic amino acids.
关键词Synthetic Methods Solid-phase Synthesis Amidation Peptides Total Synthesis
资助信息Independent Research Program of the Chinese Academy of Sciences [KSCX2-EW-J-24]; Independent Research Program of the Chinese Academy of Sciences [KSCX2-EW-J-24]; National Natural Science Foundation of China [31270273, 31070192, 30770167]; Basic Research Program from the Ministry of Science and Technology of China [2007FY110100]; National Natural Science Foundation of China [31270273, 31070192, 30770167]; Basic Research Program from the Ministry of Science and Technology of China [2007FY110100]
学科领域Chemistry, Organic
DOI10.1002/ejoc.201403145
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000345506700007
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18474
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn
作者单位1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
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GB/T 7714
Fang, Lijing,Wu, Chunlei,Yu, Zaidan,et al. Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014,67(34):7572-7576.
APA Fang, Lijing.,Wu, Chunlei.,Yu, Zaidan.,Shang, Peng.,Cheng, Yongxian.,...&wu.su@siat.ac.cn.(2014).Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,67(34),7572-7576.
MLA Fang, Lijing,et al."Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 67.34(2014):7572-7576.
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