| Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A | |
| Fang, Lijing1; Wu, Chunlei1; Yu, Zaidan1; Shang, Peng1; Cheng, Yongxian2; Peng, Yuefeng1; Su, Wu1; Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn | |
| 2014-12-01 | |
| Source Publication | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| ISSN | 1434-193X |
| Volume | 67Issue:34Pages:7572-7576 |
| Contribution Rank | 第三 |
| Abstract | A reproducible, highly efficient, and racemization-free protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids was developed. The efficiency of the reaction was demonstrated by the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. This protocol will broaden the application of triphosgene in the synthesis of a wide range of peptides, including aromatic amino acids, N-alkylated amino acids, as well as proteinogenic amino acids. |
| Keyword | Synthetic Methods Solid-phase Synthesis Amidation Peptides Total Synthesis |
| Subject Area | Chemistry, Organic |
| DOI | 10.1002/ejoc.201403145 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Organic |
| WOS ID | WOS:000345506700007 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/18474 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn |
| Affiliation | 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Fang, Lijing,Wu, Chunlei,Yu, Zaidan,et al. Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014,67(34):7572-7576. |
| APA | Fang, Lijing.,Wu, Chunlei.,Yu, Zaidan.,Shang, Peng.,Cheng, Yongxian.,...&wu.su@siat.ac.cn.(2014).Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,67(34),7572-7576. |
| MLA | Fang, Lijing,et al."Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 67.34(2014):7572-7576. |
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