Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A
Fang, Lijing1; Wu, Chunlei1; Yu, Zaidan1; Shang, Peng1; Cheng, Yongxian2; Peng, Yuefeng1; Su, Wu1; Peng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn
2014-12-01
Source PublicationEUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN1434-193X
Volume67Issue:34Pages:7572-7576
Contribution Rank第三
AbstractA reproducible, highly efficient, and racemization-free protocol for the triphosgene-mediated solid-phase coupling of proteinogenic amino acids was developed. The efficiency of the reaction was demonstrated by the first total synthesis of the bioactive natural octacyclopeptide brachystemin A. This protocol will broaden the application of triphosgene in the synthesis of a wide range of peptides, including aromatic amino acids, N-alkylated amino acids, as well as proteinogenic amino acids.
KeywordSynthetic Methods Solid-phase Synthesis Amidation Peptides Total Synthesis
Subject AreaChemistry, Organic
DOI10.1002/ejoc.201403145
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000345506700007
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18474
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorPeng,YF (reprint author),Chinese Acad Sci,Shenzhen Inst Adv Technol,Inst Biomed & Biotechnol,Guangdong Key Lab Nanomed,1068 Xueyuan Ave,Shenzhen 518055,Guangdong,Peoples R China.; yuefeng.peng@fda.hhs.gov; wu.su@siat.ac.cn
Affiliation1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Guangdong Key Lab Nanomed, Shenzhen 518055, Guangdong, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Fang, Lijing,Wu, Chunlei,Yu, Zaidan,et al. Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014,67(34):7572-7576.
APA Fang, Lijing.,Wu, Chunlei.,Yu, Zaidan.,Shang, Peng.,Cheng, Yongxian.,...&wu.su@siat.ac.cn.(2014).Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,67(34),7572-7576.
MLA Fang, Lijing,et al."Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 67.34(2014):7572-7576.
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