Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica
Lv, Jun-Jiang1,2; Wang, Ya-Feng3; Zhang, Jing-Min3,4; Yu, Shan1,2; Wang, Dong1; Zhu, Hong-Tao1; Cheng, Rong-Rong1; Yang, Chong-Ren1; Xu, Min1; Zhang, Ying-Jun1; Xu,M (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; minxu@mail.kib.ac.cn; zhangyj@mail.kib.ac.cn
2014
发表期刊ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0520
卷号12期号:43页码:8764-8774
产权排序第一
摘要During the process exploring anti-viral compounds from Phyllanthus species, eight new highly oxygenated bisabolane sesquiterpenoid glycoside phyllaemblicins G1-G8 (1-8) were isolated from Phyllanthus emblica, along with three known compounds, phyllaemblicin F (9), phyllaemblic acid (10) and glochicoccin D (11). Phyllaemblicin G2 (2), bearing a tricyclo [3.1.1.1] oxygen bridge ring system, is an unusual sesquiterpenoid glycoside, while phyllaemblicins G6-G8 (6-8) are dimeric sesquiterpenoid glycosides with two norbisabolane units connecting through a disaccharide. All the structures were elucidated by the extensive analysis of HRMS and NMR data. The relative configuration of phyllaemblicin G2 was constructed based on heteronuclear coupling constants measurement, and the absolute configurations for all new compounds were established by calculated electronic circular dichroism (ECD) using time dependent density functional theory. The sesquiterpenoid glycoside dimers 6-9 displayed potential anti-hepatitis B virus (HBV) activities, especially for the new compound 6 with IC50 of 8.53 +/- 0.97 and 5.68 +/- 1.75 mu M towards the HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively.
关键词Constituents Model Aspongopus Chinensis Insects Norepinephrine Derivatives Sesquiterpenoids Lactam Biological Evaluation
资助信息National Basic Research Program of China (973 Program) [2009CB522300]; National Basic Research Program of China (973 Program) [2009CB522300]; National Natural Sciences Foundation of China [U113260, 81102346]; Hebei University; National Natural Sciences Foundation of China [U113260, 81102346]; Hebei University
学科领域Chemistry, Organic
DOI10.1039/c4ob01196a
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000343990200024
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18464
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Xu,M (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; minxu@mail.kib.ac.cn; zhangyj@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China
4.Zhengzhou Univ, Acad Med & Pharmaceut Sci, Henan Key Lab Pharmacol Liver Dis, Zhengzhou 450052, Peoples R China
推荐引用方式
GB/T 7714
Lv, Jun-Jiang,Wang, Ya-Feng,Zhang, Jing-Min,et al. Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(43):8764-8774.
APA Lv, Jun-Jiang.,Wang, Ya-Feng.,Zhang, Jing-Min.,Yu, Shan.,Wang, Dong.,...&zhangyj@mail.kib.ac.cn.(2014).Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica.ORGANIC & BIOMOLECULAR CHEMISTRY,12(43),8764-8774.
MLA Lv, Jun-Jiang,et al."Anti-hepatitis B virus activities and absolute configurations of sesquiterpenoid glycosides from Phyllanthus emblica".ORGANIC & BIOMOLECULAR CHEMISTRY 12.43(2014):8764-8774.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Lv-2014-Anti-hepatit(1935KB) 开放获取CC BY-NC-ND请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lv, Jun-Jiang]的文章
[Wang, Ya-Feng]的文章
[Zhang, Jing-Min]的文章
百度学术
百度学术中相似的文章
[Lv, Jun-Jiang]的文章
[Wang, Ya-Feng]的文章
[Zhang, Jing-Min]的文章
必应学术
必应学术中相似的文章
[Lv, Jun-Jiang]的文章
[Wang, Ya-Feng]的文章
[Zhang, Jing-Min]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。