Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference
Xu, Li; Shi, Xiaohuo; Hu, Kaifeng; Hu,KF (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,132 Lanhei Rd,Kunming 650201,Yunnan,Peoples R China.; kaifenghu@mail.kib.ac.cn
2014-12-01
Source PublicationMAGNETIC RESONANCE IN CHEMISTRY
ISSN0749-1581
Volume52Issue:12Pages:779-782
Contribution Rank第一
AbstractOne-dimensional (1D) quantitative NMR (qNMR) is a useful tool for concentration determination due to its experimental simplicity and the direct proportionality of the integrated signal area to the number of nuclei spin. For complex mixtures, however, signal overlapping often in one-dimensional quantitative H-1 NMR (1D H-1 qNMR) spectrum limits the accurate quantification of individual compound. Here, we introduced employing joint 1D qNMR methods of different nuclei, such as H-1 and P-31 (or/and F-19), to quantify multiple compounds in a complex mixture using a single universal concentration reference. When the concentration ratio of several compounds containing different elements in a complex mixture is of interest, the result calculated from measured intensities from 1D qNMR of different nuclei is independent of the gravimetric error from the reference. In this case, the common reference also serves as a quantitative bridge' among these 1D qNMR of different nuclei. Quantitative analysis of choline, phosphocholine, and glycerophosphocholine mixture is given as an example using trimethylphosphine oxide ((CH3)(3)P(O)) as concentration reference. Compounds containing multiple elements, such as tetramethylammonium hexafluorophosphate (N+(CH3)(4)PF6-), are proposed as the common concentration reference for H-1, C-13, N-15, P-31, and F-19 qNMR for the quantitative analysis of complex mixture containing these different elements. We anticipate that the proposed joint 1D qNMR approach using a universal concentration reference will be a valuable alternative for simultaneous quantification of multiple compounds in a complex mixture due to its accuracy and single and simple sample preparation. Copyright (c) 2014 John Wiley & Sons, Ltd.
KeywordJoint 1d Qnmr Universal Concentration Reference Trimethylphosphine Oxide
Subject AreaChemistry, Multidisciplinary ; Chemistry, Physical ; Spectroscopy
DOI10.1002/mrc.4157
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Spectroscopy
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Spectroscopy
WOS IDWOS:000345509000007
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18458
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHu,KF (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,132 Lanhei Rd,Kunming 650201,Yunnan,Peoples R China.; kaifenghu@mail.kib.ac.cn
AffiliationChinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Xu, Li,Shi, Xiaohuo,Hu, Kaifeng,et al. Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference[J]. MAGNETIC RESONANCE IN CHEMISTRY,2014,52(12):779-782.
APA Xu, Li,Shi, Xiaohuo,Hu, Kaifeng,Hu,KF ,&kaifenghu@mail.kib.ac.cn.(2014).Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference.MAGNETIC RESONANCE IN CHEMISTRY,52(12),779-782.
MLA Xu, Li,et al."Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference".MAGNETIC RESONANCE IN CHEMISTRY 52.12(2014):779-782.
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