Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference
Xu, Li; Shi, Xiaohuo; Hu, Kaifeng; Hu,KF (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,132 Lanhei Rd,Kunming 650201,Yunnan,Peoples R China.; kaifenghu@mail.kib.ac.cn
2014-12-01
发表期刊MAGNETIC RESONANCE IN CHEMISTRY
ISSN0749-1581
卷号52期号:12页码:779-782
摘要One-dimensional (1D) quantitative NMR (qNMR) is a useful tool for concentration determination due to its experimental simplicity and the direct proportionality of the integrated signal area to the number of nuclei spin. For complex mixtures, however, signal overlapping often in one-dimensional quantitative H-1 NMR (1D H-1 qNMR) spectrum limits the accurate quantification of individual compound. Here, we introduced employing joint 1D qNMR methods of different nuclei, such as H-1 and P-31 (or/and F-19), to quantify multiple compounds in a complex mixture using a single universal concentration reference. When the concentration ratio of several compounds containing different elements in a complex mixture is of interest, the result calculated from measured intensities from 1D qNMR of different nuclei is independent of the gravimetric error from the reference. In this case, the common reference also serves as a quantitative bridge' among these 1D qNMR of different nuclei. Quantitative analysis of choline, phosphocholine, and glycerophosphocholine mixture is given as an example using trimethylphosphine oxide ((CH3)(3)P(O)) as concentration reference. Compounds containing multiple elements, such as tetramethylammonium hexafluorophosphate (N+(CH3)(4)PF6-), are proposed as the common concentration reference for H-1, C-13, N-15, P-31, and F-19 qNMR for the quantitative analysis of complex mixture containing these different elements. We anticipate that the proposed joint 1D qNMR approach using a universal concentration reference will be a valuable alternative for simultaneous quantification of multiple compounds in a complex mixture due to its accuracy and single and simple sample preparation. Copyright (c) 2014 John Wiley & Sons, Ltd.
关键词Joint 1d Qnmr Universal Concentration Reference Trimethylphosphine Oxide
资助信息Major State Basic Research Development Program [2010CB951700]; Major State Basic Research Development Program [2010CB951700]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2012HB041]; National Science Foundation of China [31170256, 31260167]; Young Academic and Technical Leader Raising Foundation of Yunnan Province [2012HB041]; National Science Foundation of China [31170256, 31260167]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18458
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Hu,KF (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,132 Lanhei Rd,Kunming 650201,Yunnan,Peoples R China.; kaifenghu@mail.kib.ac.cn
作者单位Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
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Xu, Li,Shi, Xiaohuo,Hu, Kaifeng,et al. Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference[J]. MAGNETIC RESONANCE IN CHEMISTRY,2014,52(12):779-782.
APA Xu, Li,Shi, Xiaohuo,Hu, Kaifeng,Hu,KF ,&kaifenghu@mail.kib.ac.cn.(2014).Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference.MAGNETIC RESONANCE IN CHEMISTRY,52(12),779-782.
MLA Xu, Li,et al."Quantification of multiple compounds containing heterogeneous elements in the mixture by one-dimensional nuclear magnetic resonance spectroscopy of different nuclei using a single universal concentration reference".MAGNETIC RESONANCE IN CHEMISTRY 52.12(2014):779-782.
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