Gao,H (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,Guangzhou 510632,Guangdong,Peoples R China.
Talaflavuterpenoid A (1), a new nardosinane-type sesquiterpene, was isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13, and its structure was elucidated on the basis of HR-MS, NMR, and X-ray diffraction analysis. The absolute configuration of 1 was established by comparing the experimental electronic circular dichroism (ECD) spectrum with the calculated ECD spectra. Its cytotoxic effects on five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), and antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger were evaluated. This is the first report of the presence of nardosinane-type sesquiterpene in Talaromyces sp.
1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China 2.Chinese Acad Sci, State Key Lab Mycol, Inst Microbiol, Beijing 100190, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West C, Kunming Inst Bot, Kunming 650204, Peoples R China
He,Jun-Wei;Liang,Hao-Xian;Gao,Hao;Kuang,Run-Qiao;Chen,Guo-Dong;Hu,Dan;Wang,Chuan-Xi;Liu,Xing-Zhong;Li,Yan;Yao,Xin-Sheng.Talaflavuterpenoid A, a new nardosinane-type sesquiterpene from Talaromyces flavus,JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2014,16(10):1029-1034