Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis

doi:10.1016/j.fitote.2014.07.008

	Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis
	Fu, Yan-hui1,2 ; Li, Shun-lin 1; Li, Shi-fei 1; He, Hong-ping 1; Di, Ying-tong1 ; Zhang, Yu1 ; Hao, Xiao-jiang1 ; Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
	2014-10-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	98 页码:45-52
摘要	Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1-4 exhibited inhibitory effects with IC50 values comparable to those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
关键词	Bousigonia Mekongensis Bisindole Alkaloids Mekongenines C-f Cytotoxicity
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2014.07.008
收录类别	SCI
语种	英语
WOS记录号	WOS:000343617600006
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18403
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Hainan Normal Univ, Key Lab Trop Med Plant Chem, Minist Educ, Haikou 571158, Peoples R China
推荐引用方式 GB/T 7714	Fu, Yan-hui,Li, Shun-lin,Li, Shi-fei,et al. Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis[J]. FITOTERAPIA,2014,98:45-52.
APA	Fu, Yan-hui.,Li, Shun-lin.,Li, Shi-fei.,He, Hong-ping.,Di, Ying-tong.,...&haoxj@mail.kib.ac.cn.(2014).Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.FITOTERAPIA,98,45-52.
MLA	Fu, Yan-hui,et al."Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis".FITOTERAPIA 98(2014):45-52.

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