| Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis | |
Fu, Yan-hui1,2 ; Li, Shun-lin1; Li, Shi-fei1; He, Hong-ping1; Di, Ying-tong1; Zhang, Yu1; Hao, Xiao-jiang1; Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
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| 2014-10-01 | |
| Source Publication | FITOTERAPIA
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| ISSN | 0367-326X |
| Volume | 98Pages:45-52 |
| Abstract | Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1-4 exhibited inhibitory effects with IC50 values comparable to those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved. |
| Keyword | Bousigonia Mekongensis Bisindole Alkaloids Mekongenines C-f Cytotoxicity |
| Subject Area | Pharmacology & Pharmacy |
| DOI | 10.1016/j.fitote.2014.07.008 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000343617600006 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/18403 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Hainan Normal Univ, Key Lab Trop Med Plant Chem, Minist Educ, Haikou 571158, Peoples R China |
| Recommended Citation GB/T 7714 | Fu, Yan-hui,Li, Shun-lin,Li, Shi-fei,et al. Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis[J]. FITOTERAPIA,2014,98:45-52. |
| APA | Fu, Yan-hui.,Li, Shun-lin.,Li, Shi-fei.,He, Hong-ping.,Di, Ying-tong.,...&haoxj@mail.kib.ac.cn.(2014).Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.FITOTERAPIA,98,45-52. |
| MLA | Fu, Yan-hui,et al."Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis".FITOTERAPIA 98(2014):45-52. |
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| 1-s2.0-S0367326X1400（559KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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