Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis
Fu, Yan-hui1,2; Li, Shun-lin1; Li, Shi-fei1; He, Hong-ping1; Di, Ying-tong1; Zhang, Yu1; Hao, Xiao-jiang1; Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
2014-10-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume98Pages:45-52
Contribution Rank第一
AbstractFour new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1-4 exhibited inhibitory effects with IC50 values comparable to those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
KeywordBousigonia Mekongensis Bisindole Alkaloids Mekongenines C-f Cytotoxicity
Subject AreaPharmacology & Pharmacy
DOI10.1016/j.fitote.2014.07.008
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000343617600006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18403
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Hainan Normal Univ, Key Lab Trop Med Plant Chem, Minist Educ, Haikou 571158, Peoples R China
Recommended Citation
GB/T 7714
Fu, Yan-hui,Li, Shun-lin,Li, Shi-fei,et al. Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis[J]. FITOTERAPIA,2014,98:45-52.
APA Fu, Yan-hui.,Li, Shun-lin.,Li, Shi-fei.,He, Hong-ping.,Di, Ying-tong.,...&haoxj@mail.kib.ac.cn.(2014).Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.FITOTERAPIA,98,45-52.
MLA Fu, Yan-hui,et al."Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis".FITOTERAPIA 98(2014):45-52.
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