Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis
Fu, Yan-hui1,2; Li, Shun-lin1; Li, Shi-fei1; He, Hong-ping1; Di, Ying-tong1; Zhang, Yu1; Hao, Xiao-jiang1; Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
2014-10-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号98页码:45-52
产权排序第一
摘要Four new eburnamine-aspidospermine type bisindole alkaloids, namely, mekongenines C-F (1-4), along with 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia mekongensis. Their structures with the absolute configurations were elucidated by spectroscopic methods and ECD analyses. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1-4 exhibited inhibitory effects with IC50 values comparable to those of cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
关键词Bousigonia Mekongensis Bisindole Alkaloids Mekongenines C-f Cytotoxicity
资助信息National Natural Science Foundation of China [31100259, 21302181]
学科领域Pharmacology & Pharmacy
DOI10.1016/j.fitote.2014.07.008
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000343617600006
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18403
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; zhangyu@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Hainan Normal Univ, Key Lab Trop Med Plant Chem, Minist Educ, Haikou 571158, Peoples R China
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Fu, Yan-hui,Li, Shun-lin,Li, Shi-fei,et al. Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis[J]. FITOTERAPIA,2014,98:45-52.
APA Fu, Yan-hui.,Li, Shun-lin.,Li, Shi-fei.,He, Hong-ping.,Di, Ying-tong.,...&haoxj@mail.kib.ac.cn.(2014).Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis.FITOTERAPIA,98,45-52.
MLA Fu, Yan-hui,et al."Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis".FITOTERAPIA 98(2014):45-52.
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