Tang,JS (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,Guangzhou 510632,Guangdong,Peoples R China.
Five new cardiac glycosides (1-5, namely antiaroside Y-ZC) together with 19 known compounds were obtained from the bark of Antiaris toxicaria. Their chemical structures were determined by IR, HR-ESI-MS, 1D and 2D NMR (HSQC, H-1-H-1 COSY, HMBC, ROESY). The absolute configuration of sugar unit was defined by acid hydrolysis and appropriate derivatization. Compound 1 was rare 5 beta-H-10 beta-H-19-nor-cardenolide, which might derive from decarboxylative derivative of 19-COOH cardenolide. The inhibitory effects of cardiac glycosides 1-11 on the viability of NIH-H460 lung cancer cells and their induction of Nur77 expression were evaluated and preliminary structure-activity relationship (SAR) was also discussed. (c) 2014 Elsevier B.V. All rights reserved.
1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China 2.Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Peoples R China 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
Li,Xiao-San;Hu,Meng-Jie;Liu,Jie;Liu,Qian;Huang,Zhi-Xing;Li,Shun-Lin;Hao,Xiao-Jiang;Zhang,Xiao-Kun;Yao,Xin-Sheng;Tang,Jin-Shan.Cardiac glycosides from the bark of Antiaris toxicaria,FITOTERAPIA,2014,97():71-77