Cardiac glycosides from the bark of Antiaris toxicaria

doi:10.1016/j.fitote.2014.05.013

	Cardiac glycosides from the bark of Antiaris toxicaria
	Li, Xiao-San 1; Hu, Meng-Jie 2; Liu, Jie2 ; Liu, Qian 1; Huang, Zhi-Xing 1; Li, Shun-Lin 3; Hao, Xiao-Jiang3 ; Zhang, Xiao-Kun 2; Yao, Xin-Sheng 1; Tang, Jin-Shan 1,4; Tang,JS (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,Guangzhou 510632,Guangdong,Peoples R China.; gztangjinshan@126.com
	2014-09-01
发表期刊	FITOTERAPIA
ISSN	0367-326X
卷号	97 页码:71-77
摘要	Five new cardiac glycosides (1-5, namely antiaroside Y-ZC) together with 19 known compounds were obtained from the bark of Antiaris toxicaria. Their chemical structures were determined by IR, HR-ESI-MS, 1D and 2D NMR (HSQC, H-1-H-1 COSY, HMBC, ROESY). The absolute configuration of sugar unit was defined by acid hydrolysis and appropriate derivatization. Compound 1 was rare 5 beta-H-10 beta-H-19-nor-cardenolide, which might derive from decarboxylative derivative of 19-COOH cardenolide. The inhibitory effects of cardiac glycosides 1-11 on the viability of NIH-H460 lung cancer cells and their induction of Nur77 expression were evaluated and preliminary structure-activity relationship (SAR) was also discussed. (c) 2014 Elsevier B.V. All rights reserved.
关键词	Antiaris Toxicaria Chemical Constituents Cardiac Glycoside Cytotoxicity Expression Of Nur77
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2014.05.013
收录类别	SCI
语种	英语
WOS记录号	WOS:000341346400009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18392
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Tang,JS (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,Guangzhou 510632,Guangdong,Peoples R China.; gztangjinshan@126.com
作者单位	1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China 2.Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China 3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Peoples R China 4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiao-San,Hu, Meng-Jie,Liu, Jie,et al. Cardiac glycosides from the bark of Antiaris toxicaria[J]. FITOTERAPIA,2014,97:71-77.
APA	Li, Xiao-San.,Hu, Meng-Jie.,Liu, Jie.,Liu, Qian.,Huang, Zhi-Xing.,...&gztangjinshan@126.com.(2014).Cardiac glycosides from the bark of Antiaris toxicaria.FITOTERAPIA,97,71-77.
MLA	Li, Xiao-San,et al."Cardiac glycosides from the bark of Antiaris toxicaria".FITOTERAPIA 97(2014):71-77.

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