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题名: Cardiac glycosides from the bark of Antiaris toxicaria
作者: Li, Xiao-San1; Hu, Meng-Jie2; Liu, Jie2; Liu, Qian1; Huang, Zhi-Xing1; Li, Shun-Lin3; null(郝小江)3; Zhang, Xiao-Kun2; Yao, Xin-Sheng1; Tang, Jin-Shan1, 4
刊名: FITOTERAPIA
出版日期: 2014-09-01
卷号: 97, 页码:71-77
关键词: Antiaris toxicaria ; Chemical constituents ; Cardiac glycoside ; Cytotoxicity ; Expression of Nur77
学科分类: Pharmacology & Pharmacy
DOI: 10.1016/j.fitote.2014.05.013
通讯作者: Tang,JS (reprint author),Jinan Univ,Inst Tradit Chinese Med & Nat Prod,Coll Pharm,Guangzhou 510632,Guangdong,Peoples R China. ; gztangjinshan@126.com
文章类型: Article
英文摘要: Five new cardiac glycosides (1-5, namely antiaroside Y-ZC) together with 19 known compounds were obtained from the bark of Antiaris toxicaria. Their chemical structures were determined by IR, HR-ESI-MS, 1D and 2D NMR (HSQC, H-1-H-1 COSY, HMBC, ROESY). The absolute configuration of sugar unit was defined by acid hydrolysis and appropriate derivatization. Compound 1 was rare 5 beta-H-10 beta-H-19-nor-cardenolide, which might derive from decarboxylative derivative of 19-COOH cardenolide. The inhibitory effects of cardiac glycosides 1-11 on the viability of NIH-H460 lung cancer cells and their induction of Nur77 expression were evaluated and preliminary structure-activity relationship (SAR) was also discussed. (c) 2014 Elsevier B.V. All rights reserved.
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: BREAST-CANCER ; DIGITALIS ; CARDENOLIDES ; ACTIVATION ; CARCINOMA ; DIGITOXIN ; CELLS
收录类别: SCI
语种: 英语
WOS记录号: WOS:000341346400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18392
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
2.Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

Recommended Citation:
Li,Xiao-San;Hu,Meng-Jie;Liu,Jie;Liu,Qian;Huang,Zhi-Xing;Li,Shun-Lin;Hao,Xiao-Jiang;Zhang,Xiao-Kun;Yao,Xin-Sheng;Tang,Jin-Shan.Cardiac glycosides from the bark of Antiaris toxicaria,FITOTERAPIA,2014,97():71-77
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