Cytotoxic diterpenoids from Salvia yunnanensis
Wu, Chun-Yan1; Liao, Yang1; Yang, Zi-Gang1; Yang, Xing-Wei1; Shen, Xiao-Ling2; Li, Rong-Tao3; Xu, Gang1
2014-10-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume106Issue:1Pages:171-177
Contribution Rank第一
Abstract

Forty-six abietane type diterpenoids possessing nine different fused ring systems were characterized from the roots of Salvia yunnanensis, six of which (salyunnanins A-F, 1-6) had different nor-abietane, homo-abietane, seco-abietane, and normal abietane architectures. Their structures were elucidated by comprehensive NMR and MS spectroscopic analyses. The inhibitory activities of these isolates against six human tumor lines were tested in vitro. Several of the compounds exhibited substantial cytotoxicity with IC50 values of 0.86-10.1 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

KeywordDiterpenoids Salvia Yunnanensis Lamiaceae Salyunnanins A-f Cytotoxicity
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2014.07.001
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000342258600017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18381
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorShen, Xiao-Ling; Li, Rong-Tao; Xu, Gang
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Guangzhou Univ Chinese Med, Inst Trop Med, Lab Chinese Herbal Drug Discovery, Guangzhou 510405, Guangdong, Peoples R China
3.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Peoples R China
Recommended Citation
GB/T 7714
Wu, Chun-Yan,Liao, Yang,Yang, Zi-Gang,et al. Cytotoxic diterpenoids from Salvia yunnanensis[J]. PHYTOCHEMISTRY,2014,106(1):171-177.
APA Wu, Chun-Yan.,Liao, Yang.,Yang, Zi-Gang.,Yang, Xing-Wei.,Shen, Xiao-Ling.,...&Xu, Gang.(2014).Cytotoxic diterpenoids from Salvia yunnanensis.PHYTOCHEMISTRY,106(1),171-177.
MLA Wu, Chun-Yan,et al."Cytotoxic diterpenoids from Salvia yunnanensis".PHYTOCHEMISTRY 106.1(2014):171-177.
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