Shen,XL (reprint author),Guangzhou Univ Chinese Med,Inst Trop Med,Lab Chinese Herbal Drug Discovery,Guangzhou 510405,Guangdong,Peoples R China.
Forty-six abietane type diterpenoids possessing nine different fused ring systems were characterized from the roots of Salvia yunnanensis, six of which (salyunnanins A-F, 1-6) had different nor-abietane, homo-abietane, seco-abietane, and normal abietane architectures. Their structures were elucidated by comprehensive NMR and MS spectroscopic analyses. The inhibitory activities of these isolates against six human tumor lines were tested in vitro. Several of the compounds exhibited substantial cytotoxicity with IC50 values of 0.86-10.1 mu M. (C) 2014 Elsevier Ltd. All rights reserved.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Guangzhou Univ Chinese Med, Inst Trop Med, Lab Chinese Herbal Drug Discovery, Guangzhou 510405, Guangdong, Peoples R China 3.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Peoples R China
Wu,Chun-Yan;Liao,Yang;Yang,Zi-Gang;Yang,Xing-Wei;Shen,Xiao-Ling;Li,Rong-Tao;Xu,Gang.Cytotoxic diterpenoids from Salvia yunnanensis,PHYTOCHEMISTRY,2014,106():171-177