Cytotoxic diterpenoids from Salvia yunnanensis
Wu, Chun-Yan1; Liao, Yang1; Yang, Zi-Gang1; Yang, Xing-Wei1; Shen, Xiao-Ling2; Li, Rong-Tao3; Xu, Gang1
2014-10-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号106期号:1页码:171-177
摘要

Forty-six abietane type diterpenoids possessing nine different fused ring systems were characterized from the roots of Salvia yunnanensis, six of which (salyunnanins A-F, 1-6) had different nor-abietane, homo-abietane, seco-abietane, and normal abietane architectures. Their structures were elucidated by comprehensive NMR and MS spectroscopic analyses. The inhibitory activities of these isolates against six human tumor lines were tested in vitro. Several of the compounds exhibited substantial cytotoxicity with IC50 values of 0.86-10.1 mu M. (C) 2014 Elsevier Ltd. All rights reserved.

关键词Diterpenoids Salvia Yunnanensis Lamiaceae Salyunnanins A-f Cytotoxicity
资助信息foundation from NSFC [81373291, 20702054]; CAS [KSCX2-EW-J-24]; SLAB [G102404]; Young Academic Leader Raising Foundation of Yunnan Province [2009CI073]; foundation from CAS
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18381
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Shen, Xiao-Ling; Li, Rong-Tao; Xu, Gang
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Guangzhou Univ Chinese Med, Inst Trop Med, Lab Chinese Herbal Drug Discovery, Guangzhou 510405, Guangdong, Peoples R China
3.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650050, Peoples R China
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GB/T 7714
Wu, Chun-Yan,Liao, Yang,Yang, Zi-Gang,et al. Cytotoxic diterpenoids from Salvia yunnanensis[J]. PHYTOCHEMISTRY,2014,106(1):171-177.
APA Wu, Chun-Yan.,Liao, Yang.,Yang, Zi-Gang.,Yang, Xing-Wei.,Shen, Xiao-Ling.,...&Xu, Gang.(2014).Cytotoxic diterpenoids from Salvia yunnanensis.PHYTOCHEMISTRY,106(1),171-177.
MLA Wu, Chun-Yan,et al."Cytotoxic diterpenoids from Salvia yunnanensis".PHYTOCHEMISTRY 106.1(2014):171-177.
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