| Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum | |
Zhang, Jing-Jing1,3; Yang, Jing1,2; Liao, Yang1,3; Yang, Xing-Wei1,3 ; Ma, Jun-Zeng1; Xiao, Qiu-Li1; Yang, Li-Xin1; Xu, Gang1; Xu,G (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; xugang008@mail.kib.ac.cn
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| 2014-09-19 | |
| 发表期刊 | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| 卷号 | 16期号:18页码:4912-4915 |
| 摘要 | Hyperuralone A (1), a polycyclic polyprenylated acylphloroglucinol possessing an unprecedented tetracyclo[5.3.1.1(4,9).0(4,11)]-dodecane core, was characterized from Hypericum uralum together with hyperuralone B (2), a congener with another complex caged skeleton. Their structures were determined by extensive spectroscopic analysis and ECD calculations. A plausible biosynthetic pathway of their intriguing architectures via intramolecular Die Is Alder reactions was also proposed. Compound 1 exhibited obviously cytotoxic activities against five human cancer cell lines in vitro (IC50 4.6-14.4 mu M). |
| 关键词 | Polycyclic Polyprenylated Acylphloroglucinols Diels-alder Reaction Natural-products Biosynthesis Annulation Chemistry Synthase |
| 学科领域 | Chemistry |
| DOI | 10.1021/ol502425f |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000342117600056 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18377 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Xu,G (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; xugang008@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jing-Jing,Yang, Jing,Liao, Yang,et al. Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum[J]. ORGANIC LETTERS,2014,16(18):4912-4915. |
| APA | Zhang, Jing-Jing.,Yang, Jing.,Liao, Yang.,Yang, Xing-Wei.,Ma, Jun-Zeng.,...&xugang008@mail.kib.ac.cn.(2014).Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum.ORGANIC LETTERS,16(18),4912-4915. |
| MLA | Zhang, Jing-Jing,et al."Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum".ORGANIC LETTERS 16.18(2014):4912-4915. |
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