Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum

doi:10.1021/ol502425f

	Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum
	Zhang, Jing-Jing 1,3; Yang, Jing 1,2; Liao, Yang 1,3; Yang, Xing-Wei1,3 ; Ma, Jun-Zeng 1; Xiao, Qiu-Li 1; Yang, Li-Xin 1; Xu, Gang1 ; Xu,G (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; xugang008@mail.kib.ac.cn
	2014-09-19
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	16 期号:18 页码:4912-4915
摘要	Hyperuralone A (1), a polycyclic polyprenylated acylphloroglucinol possessing an unprecedented tetracyclo[5.3.1.1(4,9).0(4,11)]-dodecane core, was characterized from Hypericum uralum together with hyperuralone B (2), a congener with another complex caged skeleton. Their structures were determined by extensive spectroscopic analysis and ECD calculations. A plausible biosynthetic pathway of their intriguing architectures via intramolecular Die Is Alder reactions was also proposed. Compound 1 exhibited obviously cytotoxic activities against five human cancer cell lines in vitro (IC50 4.6-14.4 mu M).
关键词	Polycyclic Polyprenylated Acylphloroglucinols Diels-alder Reaction Natural-products Biosynthesis Annulation Chemistry Synthase
学科领域	Chemistry
DOI	10.1021/ol502425f
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000342117600056
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18377
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Xu,G (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; xugang008@mail.kib.ac.cn
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jing-Jing,Yang, Jing,Liao, Yang,et al. Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum[J]. ORGANIC LETTERS,2014,16(18):4912-4915.
APA	Zhang, Jing-Jing.,Yang, Jing.,Liao, Yang.,Yang, Xing-Wei.,Ma, Jun-Zeng.,...&xugang008@mail.kib.ac.cn.(2014).Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum.ORGANIC LETTERS,16(18),4912-4915.
MLA	Zhang, Jing-Jing,et al."Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum".ORGANIC LETTERS 16.18(2014):4912-4915.

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