Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea

doi:10.1016/j.steroids.2006.04.005

	Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea
	Zhang, Ying ; Li, Hai-Zhou ; Zhang, Ying-Jun; Jacob, Melissa R.; Khan, Shabana I.; Li, Xing-Cong ; Yang, Chong-Ren
	2006-08-01
发表期刊	STEROIDS
ISSN	0039-128X
卷号	71 期号:8 页码:712-719
摘要	Atropurosides A-G (1-7), seven new steroidal saponins, which possess new polyhydroxylated aglycones, were isolated from the rhizomes of Smilacina atropurpurea (Convallariaceae), together with a known saponin, dioscin (8). Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. Antifungal testing of the eight compounds indicated that atropurosides B (2) and F (6) were fungicidal against Candida albicans, Candida glabrata, Cryptococcus neoformans, and Aspergillus fumigatus with minimum fungicidal concentrations (MFCs) <= 20 mu g/ml, while dioscin (8) was selectively active against C. albicans and C. glabrata (MFC < 5.0 mu g/ml). Furthermore, the antifungal saponins 2, 6, and 8 were evaluated for their in vitro cytotoxicities in a panel of human cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3, and HepG2) and noncancerous Vero cells. All showed moderate cytotoxicities. It appears that the antifungal activity of these steroidal saponins correlates with their cytotoxicity against mammalian cells. (c) 2006 Elsevier Inc. All rights reserved.
关键词	Smilacina Atropurpurea Steroidal Saponins Atropurosides A-f Antifungal Activities Cytotoxicity
学科领域	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI	10.1016/j.steroids.2006.04.005
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000239224300010
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/1835
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
推荐引用方式 GB/T 7714	Zhang, Ying,Li, Hai-Zhou,Zhang, Ying-Jun,et al. Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea[J]. STEROIDS,2006,71(8):712-719.
APA	Zhang, Ying.,Li, Hai-Zhou.,Zhang, Ying-Jun.,Jacob, Melissa R..,Khan, Shabana I..,...&Yang, Chong-Ren.(2006).Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea.STEROIDS,71(8),712-719.
MLA	Zhang, Ying,et al."Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea".STEROIDS 71.8(2006):712-719.

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