Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea
Zhang, Ying; Li, Hai-Zhou; Zhang, Ying-Jun; Jacob, Melissa R.; Khan, Shabana I.; Li, Xing-Cong; Yang, Chong-Ren
2006-08-01
发表期刊STEROIDS
ISSN0039-128X
卷号71期号:8页码:712-719
摘要Atropurosides A-G (1-7), seven new steroidal saponins, which possess new polyhydroxylated aglycones, were isolated from the rhizomes of Smilacina atropurpurea (Convallariaceae), together with a known saponin, dioscin (8). Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. Antifungal testing of the eight compounds indicated that atropurosides B (2) and F (6) were fungicidal against Candida albicans, Candida glabrata, Cryptococcus neoformans, and Aspergillus fumigatus with minimum fungicidal concentrations (MFCs) <= 20 mu g/ml, while dioscin (8) was selectively active against C. albicans and C. glabrata (MFC < 5.0 mu g/ml). Furthermore, the antifungal saponins 2, 6, and 8 were evaluated for their in vitro cytotoxicities in a panel of human cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3, and HepG2) and noncancerous Vero cells. All showed moderate cytotoxicities. It appears that the antifungal activity of these steroidal saponins correlates with their cytotoxicity against mammalian cells. (c) 2006 Elsevier Inc. All rights reserved.
关键词Smilacina Atropurpurea Steroidal Saponins Atropurosides A-f Antifungal Activities Cytotoxicity
学科领域Biochemistry & Molecular Biology ; Endocrinology & Metabolism
DOI10.1016/j.steroids.2006.04.005
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS类目Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS记录号WOS:000239224300010
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1835
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA
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GB/T 7714
Zhang, Ying,Li, Hai-Zhou,Zhang, Ying-Jun,et al. Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea[J]. STEROIDS,2006,71(8):712-719.
APA Zhang, Ying.,Li, Hai-Zhou.,Zhang, Ying-Jun.,Jacob, Melissa R..,Khan, Shabana I..,...&Yang, Chong-Ren.(2006).Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea.STEROIDS,71(8),712-719.
MLA Zhang, Ying,et al."Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea".STEROIDS 71.8(2006):712-719.
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