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题名: Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea
作者: Zhang, Ying; Li, Hai-Zhou; null(张颖君); Jacob, Melissa R.; Khan, Shabana I.; Li, Xing-Cong; Yang, Chong-Ren
刊名: STEROIDS
关键词: Smilacina atropurpurea ; steroidal saponins ; atropurosides A-F ; antifungal activities ; cytotoxicity
英文摘要: Atropurosides A-G (1-7), seven new steroidal saponins, which possess new polyhydroxylated aglycones, were isolated from the rhizomes of Smilacina atropurpurea (Convallariaceae), together with a known saponin, dioscin (8). Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. Antifungal testing of the eight compounds indicated that atropurosides B (2) and F (6) were fungicidal against Candida albicans, Candida glabrata, Cryptococcus neoformans, and Aspergillus fumigatus with minimum fungicidal concentrations (MFCs) <= 20 mu g/ml, while dioscin (8) was selectively active against C. albicans and C. glabrata (MFC < 5.0 mu g/ml). Furthermore, the antifungal saponins 2, 6, and 8 were evaluated for their in vitro cytotoxicities in a panel of human cancer cell lines (SK-MEL, KB, BT-549, SK-OV-3, and HepG2) and noncancerous Vero cells. All showed moderate cytotoxicities. It appears that the antifungal activity of these steroidal saponins correlates with their cytotoxicity against mammalian cells. (c) 2006 Elsevier Inc. All rights reserved.
出版日期: 2006-08-01
卷号: 71, 期号:8, 页码:712-719
DOI标识: 10.1016/j.steroids.2006.04.005
语种: 英语
ISSN号: 0039-128X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1835
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

Recommended Citation:
Zhang, Y; Li, HZ; Zhang, YJ; Jacob, MR; Khan, SI; Li, XC; Yang, CR.Atropurosides A-G, new steroidal saponins from Smilacina atropurpurea,STEROIDS,2006,71(8):712-719
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