Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana

doi:10.1016/j.tet.2014.06.030

	Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana
	Saito, Yoshinori 1; Sasaki, Yoko 1; Komiyama, Teppei 2; Ohsaki, Ayumi 2; Okamoto, Yasuko 1; Gong, Xun3 ; Kuroda, Chiaki 4,5; Tori, Motoo 1
	2014-09-02
发表期刊	TETRAHEDRON
ISSN	0040-4020
卷号	70 期号:35 页码:5878-5883
摘要	Five new 12-oxygenated eremophilane sesquiterpenoids bearing a B-ring enone system were isolated from Ligularia lingiana S.W. Liu (Asteraceae) collected in China. Compound 5 was a Diels-Alder adduct of 3 alpha-angeloyloxy-7 beta H-8-oxoeremophila-9,11(13)-dien-12-al and the monoterpene, ocimene. Compound I showed cytotoxic activities against HeLa, HL60, Jurkat, and NIH-3T3 cells at IC50 0.0407, 0.440, 0.313, and 3.48 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
关键词	Asteraceae Ligularia Lingiana Sesquiterpenoid Eremophilane Dimer
学科领域	Chemistry, Organic
DOI	10.1016/j.tet.2014.06.030
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000340336000064
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18306
专题	资源植物与生物技术所级重点实验室
通讯作者	Gong, Xun; Kuroda, Chiaki; Tori, Motoo
作者单位	1.Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan 2.Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China 4.Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan 5.Rikkyo Univ, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan
推荐引用方式 GB/T 7714	Saito, Yoshinori,Sasaki, Yoko,Komiyama, Teppei,et al. Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana[J]. TETRAHEDRON,2014,70(35):5878-5883.
APA	Saito, Yoshinori.,Sasaki, Yoko.,Komiyama, Teppei.,Ohsaki, Ayumi.,Okamoto, Yasuko.,...&Tori, Motoo.(2014).Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana.TETRAHEDRON,70(35),5878-5883.
MLA	Saito, Yoshinori,et al."Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana".TETRAHEDRON 70.35(2014):5878-5883.

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