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Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana
Saito, Yoshinori1; Sasaki, Yoko1; Komiyama, Teppei2; Ohsaki, Ayumi2; Okamoto, Yasuko1; Gong, Xun3; Kuroda, Chiaki4,5; Tori, Motoo1
2014-09-02
Source PublicationTETRAHEDRON
ISSN0040-4020
Volume70Issue:35Pages:5878-5883
Contribution Rank第三
Abstract

Five new 12-oxygenated eremophilane sesquiterpenoids bearing a B-ring enone system were isolated from Ligularia lingiana S.W. Liu (Asteraceae) collected in China. Compound 5 was a Diels-Alder adduct of 3 alpha-angeloyloxy-7 beta H-8-oxoeremophila-9,11(13)-dien-12-al and the monoterpene, ocimene. Compound I showed cytotoxic activities against HeLa, HL60, Jurkat, and NIH-3T3 cells at IC50 0.0407, 0.440, 0.313, and 3.48 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

KeywordAsteraceae Ligularia Lingiana Sesquiterpenoid Eremophilane Dimer
Subject AreaChemistry, Organic
DOI10.1016/j.tet.2014.06.030
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000340336000064
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18306
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorGong, Xun; Kuroda, Chiaki; Tori, Motoo
Affiliation1.Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan
2.Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan
5.Rikkyo Univ, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan
Recommended Citation
GB/T 7714
Saito, Yoshinori,Sasaki, Yoko,Komiyama, Teppei,et al. Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana[J]. TETRAHEDRON,2014,70(35):5878-5883.
APA Saito, Yoshinori.,Sasaki, Yoko.,Komiyama, Teppei.,Ohsaki, Ayumi.,Okamoto, Yasuko.,...&Tori, Motoo.(2014).Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana.TETRAHEDRON,70(35),5878-5883.
MLA Saito, Yoshinori,et al."Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana".TETRAHEDRON 70.35(2014):5878-5883.
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