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题名: Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana
作者: Saito, Yoshinori1; Sasaki, Yoko1; Komiyama, Teppei2; Ohsaki, Ayumi2; Okamoto, Yasuko1; null(龚洵)3; Kuroda, Chiaki4, 5; Tori, Motoo1
刊名: TETRAHEDRON
关键词: Asteraceae ; Ligularia lingiana ; Sesquiterpenoid ; Eremophilane ; Dimer
英文摘要: Five new 12-oxygenated eremophilane sesquiterpenoids bearing a B-ring enone system were isolated from Ligularia lingiana S.W. Liu (Asteraceae) collected in China. Compound 5 was a Diels-Alder adduct of 3 alpha-angeloyloxy-7 beta H-8-oxoeremophila-9,11(13)-dien-12-al and the monoterpene, ocimene. Compound I showed cytotoxic activities against HeLa, HL60, Jurkat, and NIH-3T3 cells at IC50 0.0407, 0.440, 0.313, and 3.48 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
出版日期: 2014-09-02
卷号: 70, 期号:35, 页码:5878-5883
DOI标识: 10.1016/j.tet.2014.06.030
语种: 英语
ISSN号: 0040-4020
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18306
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan
2.Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan
5.Rikkyo Univ, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan

Recommended Citation:
Saito,Yoshinori;Sasaki,Yoko;Komiyama,Teppei;Ohsaki,Ayumi;Okamoto,Yasuko;Gong,Xun;Kuroda,Chiaki;Tori,Motoo.Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana,TETRAHEDRON,2014,70(35):5878-5883
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