Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana
Saito, Yoshinori1; Sasaki, Yoko1; Komiyama, Teppei2; Ohsaki, Ayumi2; Okamoto, Yasuko1; Gong, Xun3; Kuroda, Chiaki4,5; Tori, Motoo1; Gong, X (reprint author), Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China.; gongxun@mail.kib.ac.cn; chkkuroda@rikkyo.ac.jp; tori@ph.bunri-u.ac.jp
2014-09-02
发表期刊TETRAHEDRON
ISSN0040-4020
卷号70期号:35页码:5878-5883
产权排序第三
摘要Five new 12-oxygenated eremophilane sesquiterpenoids bearing a B-ring enone system were isolated from Ligularia lingiana S.W. Liu (Asteraceae) collected in China. Compound 5 was a Diels-Alder adduct of 3 alpha-angeloyloxy-7 beta H-8-oxoeremophila-9,11(13)-dien-12-al and the monoterpene, ocimene. Compound I showed cytotoxic activities against HeLa, HL60, Jurkat, and NIH-3T3 cells at IC50 0.0407, 0.440, 0.313, and 3.48 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Asteraceae Ligularia Lingiana Sesquiterpenoid Eremophilane Dimer
资助信息Japan Society for the Promotion of Science [21404009]
学科领域Chemistry, Organic
DOI10.1016/j.tet.2014.06.030
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000340336000064
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18306
专题资源植物与生物技术所级重点实验室
通讯作者Gong, X (reprint author), Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China.; gongxun@mail.kib.ac.cn; chkkuroda@rikkyo.ac.jp; tori@ph.bunri-u.ac.jp
作者单位1.Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan
2.Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan
5.Rikkyo Univ, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan
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Saito, Yoshinori,Sasaki, Yoko,Komiyama, Teppei,et al. Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana[J]. TETRAHEDRON,2014,70(35):5878-5883.
APA Saito, Yoshinori.,Sasaki, Yoko.,Komiyama, Teppei.,Ohsaki, Ayumi.,Okamoto, Yasuko.,...&tori@ph.bunri-u.ac.jp.(2014).Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana.TETRAHEDRON,70(35),5878-5883.
MLA Saito, Yoshinori,et al."Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana".TETRAHEDRON 70.35(2014):5878-5883.
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