Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana
Saito, Yoshinori1; Sasaki, Yoko1; Komiyama, Teppei2; Ohsaki, Ayumi2; Okamoto, Yasuko1; Gong, Xun3; Kuroda, Chiaki4,5; Tori, Motoo1
2014-09-02
发表期刊TETRAHEDRON
ISSN0040-4020
卷号70期号:35页码:5878-5883
摘要

Five new 12-oxygenated eremophilane sesquiterpenoids bearing a B-ring enone system were isolated from Ligularia lingiana S.W. Liu (Asteraceae) collected in China. Compound 5 was a Diels-Alder adduct of 3 alpha-angeloyloxy-7 beta H-8-oxoeremophila-9,11(13)-dien-12-al and the monoterpene, ocimene. Compound I showed cytotoxic activities against HeLa, HL60, Jurkat, and NIH-3T3 cells at IC50 0.0407, 0.440, 0.313, and 3.48 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

关键词Asteraceae Ligularia Lingiana Sesquiterpenoid Eremophilane Dimer
学科领域Chemistry, Organic
DOI10.1016/j.tet.2014.06.030
收录类别SCI ; IC
语种英语
WOS记录号WOS:000340336000064
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18306
专题资源植物与生物技术所级重点实验室
通讯作者Gong, Xun; Kuroda, Chiaki; Tori, Motoo
作者单位1.Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan
2.Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
4.Rikkyo Univ, Dept Chem, Toshima Ku, Tokyo 1718501, Japan
5.Rikkyo Univ, Res Ctr Smart Mol, Toshima Ku, Tokyo 1718501, Japan
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Saito, Yoshinori,Sasaki, Yoko,Komiyama, Teppei,et al. Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana[J]. TETRAHEDRON,2014,70(35):5878-5883.
APA Saito, Yoshinori.,Sasaki, Yoko.,Komiyama, Teppei.,Ohsaki, Ayumi.,Okamoto, Yasuko.,...&Tori, Motoo.(2014).Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana.TETRAHEDRON,70(35),5878-5883.
MLA Saito, Yoshinori,et al."Structure and cytotoxic evaluation of five 12-oxygenated eremophilanes from Ligularia lingiana".TETRAHEDRON 70.35(2014):5878-5883.
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