A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
Lepore, Marco1,4; de Lalla, Claudia4; Gundimeda, S. Ramanjaneyulu1; Gsellinger, Heiko2; Consonni, Michela4; Garavaglia, Claudio4; Sansano, Sebastiano1; Piccolo, Francesco4; Scelfo, Andrea4; Haeussinger, Daniel2; Montagna, Daniela7,8; Locatelli, Franco9; Bonini, Chiara5; Bondanza, Attilio5; Forcina, Alessandra6; Li, Zhiyuan10; Ni, Guanghui10; Ciceri, Fabio6; Jenoe, Paul3; Xia, Chengfeng10; Mori, Lucia1,11; Dellabona, Paolo4; Casorati, Giulia4; De Libero, Gennaro1,11; De Libero, G (reprint author), Univ Basel, Univ Hosp Basel, Dept Biomed, CH-4056 Basel, Switzerland.; lucia_mori@immunol.a-star.edu.sg; dellabona.paolo@hsr.it; casorati.giulia@hsr.it; gennaro.delibero@unibas.ch
2014-06-30
发表期刊JOURNAL OF EXPERIMENTAL MEDICINE
ISSN0022-1007
卷号211期号:7页码:1360-1374
产权排序第十
摘要T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a novel class of self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which are accumulated in leukemia cells. Primary acute myeloid and B cell acute leukemia blasts express CD1 molecules. mLPA-specific T cells efficiently kill CD1c(+) acute leukemia cells, poorly recognize nontransformed CD1c-expressing cells, and protect immuno-deficient mice against CD1c+ human leukemia cells. The identification of immunogenic self-lipid antigens accumulated in leukemia cells and the observed leukemia control by lipid-specific T cells in vivo provide a new conceptual framework for leukemia immune surveillance and possible immunotherapy.
关键词Acute Myeloid-leukemia Nkt Cells Mass-spectrometry Mycobacterium-tuberculosis Electrospray-ionization Lysophosphatidic Acid Donor Lymphocytes Immune-responses Cancer Glycolipids
资助信息Swiss National Foundation [3100AO-122464/1, Sinergia CRS133-124819]; Association for International Cancer Research; Italian Ministry of Health; Italian Association for Cancer Research (Special Program 5x1000 9965) [AIRC-IG-5804, AIRC-IG-11523]; AIRC Special Program 5x1000 9962; Yunnan High-End Technology Professionals Introduction Program [2010CI117]
学科领域Immunology ; Medicine, Research & Experimental
DOI10.1084/jem.20140410
收录类别SCI
语种英语
WOS研究方向Immunology ; Research & Experimental Medicine
WOS类目Immunology ; Medicine, Research & Experimental
WOS记录号WOS:000338927200009
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18276
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者De Libero, G (reprint author), Univ Basel, Univ Hosp Basel, Dept Biomed, CH-4056 Basel, Switzerland.; lucia_mori@immunol.a-star.edu.sg; dellabona.paolo@hsr.it; casorati.giulia@hsr.it; gennaro.delibero@unibas.ch
作者单位1.Univ Basel, Univ Hosp Basel, Dept Biomed, CH-4056 Basel, Switzerland
2.Univ Basel, Dept Chem, Nucl Magnet Resonance Lab, CH-4056 Basel, Switzerland
3.Univ Basel, Biozentrum, Dept Biochem, CH-4056 Basel, Switzerland
4.Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Expt Immunol Unit, I-20132 Milan, Italy
5.Ist Sci San Raffaele, Expt Hematol Unit, I-20132 Milan, Italy
6.Ist Sci San Raffaele, Bone Marrow Transplantat Unit, I-20132 Milan, Italy
7.Univ Pavia, Dipartimento Pediat, Immunol Lab, I-27100 Pavia, Italy
8.Fdn IRCCS Policlin San Matteo, I-27100 Pavia, Italy
9.IRCCS Bambino Gesu Hosp, Dept Pediat Hematol Oncol, I-00165 Rome, Italy
10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochemistry & Plant Resources We, Kunming 650201, Peoples R China
11.Singapore Immunol Network SIgN Agcy Sci Tech & Re, Singapore 138648, Singapore
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Lepore, Marco,de Lalla, Claudia,Gundimeda, S. Ramanjaneyulu,et al. A novel self-lipid antigen targets human T cells against CD1c(+) leukemias[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2014,211(7):1360-1374.
APA Lepore, Marco.,de Lalla, Claudia.,Gundimeda, S. Ramanjaneyulu.,Gsellinger, Heiko.,Consonni, Michela.,...&gennaro.delibero@unibas.ch.(2014).A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.JOURNAL OF EXPERIMENTAL MEDICINE,211(7),1360-1374.
MLA Lepore, Marco,et al."A novel self-lipid antigen targets human T cells against CD1c(+) leukemias".JOURNAL OF EXPERIMENTAL MEDICINE 211.7(2014):1360-1374.
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