Cytotoxic and new tetralone derivatives from Berchemia floribunda (WALL.) BRONGN.
Wang, Yi-Fen; Cao, Jian-Xin; Efferth, Thomas; Lai, Gou-Fang; Luo, Shi-De
2006
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号3期号:6页码:646-653
摘要Two new alpha-tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivatives, bercherniaside A and B (1 and 2, resp.), and one new flavonoid, quercetin-3-O-(2-acetyl-alpha-(L)-arabinofuranoside (3), together with ten known flavonoids compounds, eriodictyol (4), aromadendrin (5), trans-dihydroquercetin (6), cis-dihydroquercetin (7), kaempferol (8), kaempferol-3-O-alpha-(L)-arabinofuranoside (9), quercetin (10), quercetin-3-O-alpha-(L)-arabinofuranoside or avicularin (11), quercetin 3'-methyl ether, 3-O-alpha-(L)-arabinofuranoside (12), and maesopsin (13), were isolated from the bark of Berchemia floribunda. Their structures were determined by various NMR techniques and chemical studies. Compounds 3-13 were tested for their cytotoxic activity against human leukemia cells. Among them, kaempferol (8) and maesopsin (13) showed significant inhibitory activities against human leukemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC50 values of 14.0, 5.3, 10.2, and 12.3 mu m, respectively.
关键词Juglans-mandshurica Cell Lines Flavonoids Artesunate
学科领域Biochemistry & Molecular Biology ; Chemistry ; Multidisciplinary
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000238904600005
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1827
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.German Canc Res Ctr, D-69120 Heidelberg, Germany
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
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GB/T 7714
Wang, Yi-Fen,Cao, Jian-Xin,Efferth, Thomas,et al. Cytotoxic and new tetralone derivatives from Berchemia floribunda (WALL.) BRONGN.[J]. CHEMISTRY & BIODIVERSITY,2006,3(6):646-653.
APA Wang, Yi-Fen,Cao, Jian-Xin,Efferth, Thomas,Lai, Gou-Fang,&Luo, Shi-De.(2006).Cytotoxic and new tetralone derivatives from Berchemia floribunda (WALL.) BRONGN..CHEMISTRY & BIODIVERSITY,3(6),646-653.
MLA Wang, Yi-Fen,et al."Cytotoxic and new tetralone derivatives from Berchemia floribunda (WALL.) BRONGN.".CHEMISTRY & BIODIVERSITY 3.6(2006):646-653.
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