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题名: Cytotoxic and new tetralone derivatives from Berchemia floribunda (WALL.) BRONGN.
作者: Wang, Yi-Fen; Cao, Jian-Xin; Efferth, Thomas; Lai, Gou-Fang; Luo, Shi-De
刊名: CHEMISTRY & BIODIVERSITY
关键词: JUGLANS-MANDSHURICA ; CELL LINES ; FLAVONOIDS ; ARTESUNATE
英文摘要: Two new alpha-tetralone (=3,4-dihydronaphthalen-1(2H)-one) derivatives, bercherniaside A and B (1 and 2, resp.), and one new flavonoid, quercetin-3-O-(2-acetyl-alpha-(L)-arabinofuranoside (3), together with ten known flavonoids compounds, eriodictyol (4), aromadendrin (5), trans-dihydroquercetin (6), cis-dihydroquercetin (7), kaempferol (8), kaempferol-3-O-alpha-(L)-arabinofuranoside (9), quercetin (10), quercetin-3-O-alpha-(L)-arabinofuranoside or avicularin (11), quercetin 3'-methyl ether, 3-O-alpha-(L)-arabinofuranoside (12), and maesopsin (13), were isolated from the bark of Berchemia floribunda. Their structures were determined by various NMR techniques and chemical studies. Compounds 3-13 were tested for their cytotoxic activity against human leukemia cells. Among them, kaempferol (8) and maesopsin (13) showed significant inhibitory activities against human leukemia cells CCRF-CEM and its multidrug-resistant sub-line, CEM/ADR5000, with IC50 values of 14.0, 5.3, 10.2, and 12.3 mu m, respectively.
出版日期: 2006
卷号: 3, 期号:6, 页码:646-653
语种: 英语
ISSN号: 1612-1872
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1827
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.German Canc Res Ctr, D-69120 Heidelberg, Germany
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

Recommended Citation:
Wang, YF; Cao, JX; Efferth, T; Lai, GF; Luo, SD.Cytotoxic and new tetralone derivatives from Berchemia floribunda (WALL.) BRONGN.,CHEMISTRY & BIODIVERSITY,2006,3(6):646-653
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