Three new phenolic amides, tabamides A-C (1-3), together with three known phenolic amides (4-6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1-6 were also tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 1 exhibited high anti-TMV activity with inhibition rate of 38.6%, which is higher than that of positive control (ningnanmycin). The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 15.3-26.5%, respectively. (C) 2014 Published by Elsevier B.V. on behalf of Phytochemical Society of Europe.
1.Yunnan Acad Tobacco Sci, Key Lab Tobacco Chem Yunnan Prov, Kunming 650106, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
Shang,Shan-Zhai;Duan,Yuan-Xing;Zhang,Xia;Pu,Jian-Xin;Sun,Han-Dong;Chen,Zhang-Yu;Miao,Ming-Ming;Yang,Guang-Yu;Chen,Yong-Kuan.Phenolic amides from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities,PHYTOCHEMISTRY LETTERS,2014,9():184-187