| New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne | |
Piao, Shu-Juan1; Jiao, Wei-Hua2; Yang, Fan2; Yi, Yang-Hua1; Di, Ying-Tong3 ; Han, Bing-Nan2; Lin, Hou-Wen1; Han, BN (reprint author), Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China.; piaoshujuan@163.com; jiaoweihua1982@sina.com; bill1985@126.com; yiyanghua@126.com; diyt@mail.kib.ac.cn; hanbingnan@shsmu.edu.cn; franklin67@126.com
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| 2014-07-01 | |
| 发表期刊 | MARINE DRUGS
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| ISSN | 1660-3397 |
| 卷号 | 12期号:7页码:4096-4109 |
| 摘要 | Five new sesterterpenoids, compounds 1-5, have been isolated from the sponge Hippospongia lachne off Yongxing Island in the South China Sea. The structures of compounds 1-5 were elucidated through extensive spectroscopic analysis, including HRMS, 1D, and 2D NMR experiments. The stereochemistry, including absolute configurations of these compounds, was determined by spectroscopic, chemical, and computational methods. Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 mu M and 8.7 mu M, respectively, more potent than previously reported hippolides. |
| 关键词 | Marine Sponge Hippospongia Lachne Sesterterpenoids Absolute Configuration Ptp1b |
| 学科领域 | Chemistry, Medicinal |
| DOI | 10.3390/md12074096 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339989300019 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18267 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Han, BN (reprint author), Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China.; piaoshujuan@163.com; jiaoweihua1982@sina.com; bill1985@126.com; yiyanghua@126.com; diyt@mail.kib.ac.cn; hanbingnan@shsmu.edu.cn; franklin67@126.com |
| 作者单位 | 1.Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China 2.Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Piao, Shu-Juan,Jiao, Wei-Hua,Yang, Fan,et al. New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne[J]. MARINE DRUGS,2014,12(7):4096-4109. |
| APA | Piao, Shu-Juan.,Jiao, Wei-Hua.,Yang, Fan.,Yi, Yang-Hua.,Di, Ying-Tong.,...&franklin67@126.com.(2014).New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne.MARINE DRUGS,12(7),4096-4109. |
| MLA | Piao, Shu-Juan,et al."New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne".MARINE DRUGS 12.7(2014):4096-4109. |
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| Piao-2014-New Hippol（612KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
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