Five new sesterterpenoids, compounds 1-5, have been isolated from the sponge Hippospongia lachne off Yongxing Island in the South China Sea. The structures of compounds 1-5 were elucidated through extensive spectroscopic analysis, including HRMS, 1D, and 2D NMR experiments. The stereochemistry, including absolute configurations of these compounds, was determined by spectroscopic, chemical, and computational methods. Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 mu M and 8.7 mu M, respectively, more potent than previously reported hippolides.
1.Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China 2.Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China
Piao,Shu-Juan;Jiao,Wei-Hua;Yang,Fan;Yi,Yang-Hua;Di,Ying-Tong;Han,Bing-Nan;Lin,Hou-Wen.New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne,MARINE DRUGS,2014,12(7):4096-4109