New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne
Piao, Shu-Juan1; Jiao, Wei-Hua2; Yang, Fan2; Yi, Yang-Hua1; Di, Ying-Tong3; Han, Bing-Nan2; Lin, Hou-Wen1; Han, BN (reprint author), Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China.; piaoshujuan@163.com; jiaoweihua1982@sina.com; bill1985@126.com; yiyanghua@126.com; diyt@mail.kib.ac.cn; hanbingnan@shsmu.edu.cn; franklin67@126.com
2014-07-01
发表期刊MARINE DRUGS
ISSN1660-3397
卷号12期号:7页码:4096-4109
产权排序第三
摘要Five new sesterterpenoids, compounds 1-5, have been isolated from the sponge Hippospongia lachne off Yongxing Island in the South China Sea. The structures of compounds 1-5 were elucidated through extensive spectroscopic analysis, including HRMS, 1D, and 2D NMR experiments. The stereochemistry, including absolute configurations of these compounds, was determined by spectroscopic, chemical, and computational methods. Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 mu M and 8.7 mu M, respectively, more potent than previously reported hippolides.
关键词Marine Sponge Hippospongia Lachne Sesterterpenoids Absolute Configuration Ptp1b
资助信息National Natural Science Fund for Distinguished Young Scholars of China [81225023]; National Natural Science Fund of China [41106127, 81072573, 81172978, 81302691, 81373321, 81001394, 81202441]; Shanghai Subject Chief Scientist [12XD1400200]; Innovation Program of Shanghai Municipal Education Commission [14YZ037]; National High Technology Research and Development Program of China (863 Projects) [2011AA09070107, 2013AA092902]
学科领域Chemistry, Medicinal
DOI10.3390/md12074096
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000339989300019
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18267
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Han, BN (reprint author), Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China.; piaoshujuan@163.com; jiaoweihua1982@sina.com; bill1985@126.com; yiyanghua@126.com; diyt@mail.kib.ac.cn; hanbingnan@shsmu.edu.cn; franklin67@126.com
作者单位1.Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China
2.Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China
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Piao, Shu-Juan,Jiao, Wei-Hua,Yang, Fan,et al. New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne[J]. MARINE DRUGS,2014,12(7):4096-4109.
APA Piao, Shu-Juan.,Jiao, Wei-Hua.,Yang, Fan.,Yi, Yang-Hua.,Di, Ying-Tong.,...&franklin67@126.com.(2014).New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne.MARINE DRUGS,12(7),4096-4109.
MLA Piao, Shu-Juan,et al."New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne".MARINE DRUGS 12.7(2014):4096-4109.
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