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题名: New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne
作者: Piao, Shu-Juan1; Jiao, Wei-Hua2; Yang, Fan2; Yi, Yang-Hua1; Di, Ying-Tong3; Han, Bing-Nan2; Lin, Hou-Wen1
刊名: MARINE DRUGS
出版日期: 2014-07-01
卷号: 12, 期号:7, 页码:4096-4109
关键词: marine sponge ; Hippospongia lachne ; sesterterpenoids ; absolute configuration ; PTP1B
学科分类: Chemistry, Medicinal
DOI: 10.3390/md12074096
通讯作者: Han, BN (reprint author), Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China. ; piaoshujuan@163.com ; jiaoweihua1982@sina.com ; bill1985@126.com ; yiyanghua@126.com ; diyt@mail.kib.ac.cn ; hanbingnan@shsmu.edu.cn ; franklin67@126.com
文章类型: Article
英文摘要: Five new sesterterpenoids, compounds 1-5, have been isolated from the sponge Hippospongia lachne off Yongxing Island in the South China Sea. The structures of compounds 1-5 were elucidated through extensive spectroscopic analysis, including HRMS, 1D, and 2D NMR experiments. The stereochemistry, including absolute configurations of these compounds, was determined by spectroscopic, chemical, and computational methods. Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 mu M and 8.7 mu M, respectively, more potent than previously reported hippolides.
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: SESTERTERPENE SULFATES ; OKINAWAN SPONGE ; METACHROMIA ; SESQUITERPENOIDS
收录类别: SCI
语种: 英语
WOS记录号: WOS:000339989300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18267
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Second Mil Med Univ, Changzheng Hosp, Dept Pharm, Lab Marine Drugs, Shanghai 200003, Peoples R China
2.Shanghai Jiao Tong Univ Sch Med, Renji Hosp, Dept Pharm, Key Lab Marine Drugs, Shanghai 200127, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem & Plant Resources West China, Kunming 650201, Yunnan, Peoples R China

Recommended Citation:
Piao,Shu-Juan;Jiao,Wei-Hua;Yang,Fan;Yi,Yang-Hua;Di,Ying-Tong;Han,Bing-Nan;Lin,Hou-Wen.New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne,MARINE DRUGS,2014,12(7):4096-4109
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