Xiao, WL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China.
Six new lignans (1-6), as well as five known ones (7-11) were isolated from the leaves and stems of Schisandra chinensis. The structures of 1-6 were established on the basis of spectroscopic methods including 1D-and 2D-NMR techniques and CD experiments. Compound 1 was the first example of naturally occurring N-containing lignans featuring a nicotinoyl group. All the new compounds were evaluated for their anti-HIV-1 activities and showed EC50 values in the range 17.89-138.23 mu g/mL.
1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Shi,Yiming;Zhong,Weimao;Chen,Huan;Wang,Ruirui;Shang,Shanzhai;Liang,Chengqin;Gao,Zhonghua;Zheng,Yongtang;Xiao,Weilie;Sun,Handong.New Lignans from the Leaves and Stems of Schisandra chinensis and Their Anti-HIV-1 Activities,CHINESE JOURNAL OF CHEMISTRY,2014,32(8):734-740