Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum
Ding, Jia-Yin1,2; Yuan, Chun-Mao1; Cao, Ming-Ming1; Liu, Wei-Wei1; Yu, Chun1; Zhang, Hai-Yuan1; Zhang, Yu1; Di, Ying-Tong1; He, Hong-Ping1; Li, Shun-Lin1; Hao, Xiao-Jiang1; Li, SL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China.; lisl@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
2014-08-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号77期号:8页码:1800-1805
产权排序第一
摘要Seven new compounds, including a eupodienone-type lignan (1), a dibenzocyclooctadiene-type lignan (2), three tetrahydrofuran-type lignans (3-5), and two 1-phenyl-butyl benzoates (6, 7), together with six known compounds, were isolated from the mature carpels of Manglietiastrum sinicum. The structures of new compounds 1-7 were defined by spectroscopic techniques, and the absolute configuration of manglisin A (1) was determined by X-ray crystallography. Compounds 1-4 exhibited moderate antimicrobial activities (MIC values: 0.016-0.14 mu M) against Staphylococcus aureus, MRSA 82(#), MESA 92(#), NLRSA 98(#), and MRSA 331(#). Compounds 2 and 3 showed weak cytotoxic activity against five human tumor cell lines.
关键词Absolute-configuration Lignans Tetrahydrofuran Aggregation Inhibition Chinensis Plants Stem
资助信息National Natural Science Foundation of China [31270404]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np500187c
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000340861800006
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18253
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li, SL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China.; lisl@mail.kib.ac.cn; haoxj@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Ding, Jia-Yin,Yuan, Chun-Mao,Cao, Ming-Ming,et al. Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(8):1800-1805.
APA Ding, Jia-Yin.,Yuan, Chun-Mao.,Cao, Ming-Ming.,Liu, Wei-Wei.,Yu, Chun.,...&haoxj@mail.kib.ac.cn.(2014).Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum.JOURNAL OF NATURAL PRODUCTS,77(8),1800-1805.
MLA Ding, Jia-Yin,et al."Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum".JOURNAL OF NATURAL PRODUCTS 77.8(2014):1800-1805.
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