Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys
Li, Xian; Xiao, Weilie; Pu, Jianxin; Ban, Lili; Shen, Yunheng; Weng, Zhiying; Li, Shenghong; Sun, Handong
2006-07-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume67Issue:13Pages:1336-1340
Abstractent-Kaurene diterpenoids, phyllostachysins D-H (1-5), together with nine known compounds, rabdoloxins A-B (6-7), rabdoinflexin B (8), amethystoidin A (9), rabdokunmin D (10), macrocalyxin E (11), 5,7-dihydroxy-4'-hydroxylflavone (12), oleanolic acid (13) and daucosterol (14), were isolated from aerial parts of Isodon phyllostachys. Structures were elucidated on the basis of spectroscopic methods, especially using 2D-NMR spectroscopic analyses. All ent-kaurenoids were tested for their cytotoxic effects against K562 cells. Compound 9 was the most potent with an IC50 value of 0.69 mu g/ml. (c) 2006 Elsevier Ltd. All rights reserved.
KeywordIsodon Phyllostachys Labiatae Ent-kaurenoids Phyllostachysins D-h Cytotoxic Effect
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
DOI10.1016/j.phytochem.2006.05.002
Indexed BySCI ; IC
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000239972600007
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/1823
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China
2.Kunming Med Coll, Acad Pharmacol, Kunming 650031, Yunnan, Peoples R China
3.Kunming Med Coll, Yunnan Lab Nat Prod, Kunming 650031, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Xian,Xiao, Weilie,Pu, Jianxin,et al. Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys[J]. PHYTOCHEMISTRY,2006,67(13):1336-1340.
APA Li, Xian.,Xiao, Weilie.,Pu, Jianxin.,Ban, Lili.,Shen, Yunheng.,...&Sun, Handong.(2006).Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys.PHYTOCHEMISTRY,67(13),1336-1340.
MLA Li, Xian,et al."Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys".PHYTOCHEMISTRY 67.13(2006):1336-1340.
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