Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris
Zhao, Yong1,2; Geng, Chang-An1; Sun, Chang-Li1,2; Ma, Yun-Bao1; Huang, Xiao-Yan1; Cao, Tuan-Wu1; He, Kang1; Wang, Hao1,2; Zhang, Xue-Mei1; Chen, Ji-Jun1; Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; chenjj@mail.kib.ac.cn
2014-06-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号95页码:187-193
摘要Three new polyacetylenes, 8-(2)-decene-4, 6-diyne-1, 3, 10-triol (1), 1, 3S, 8S-trihydroxydec-9-en-4, 6-yne (2), 3S, 8S-dihydroxydec-9-en-4, 6-yne 1-O-beta -D-glucopyranoside (3), and one new glucosyl caffeoate, 1-O-ethyl-6-O-caffeoyl-beta -D-glucopyranose (4), together with 34 known compounds were isolated from Artemisia capillaris. The structures of the new compounds were determined by extensive spectroscopic analyses including 1D and 2D NMR, HRESIMS, [alpha](D) and CD experiments. Among them, 19 compounds showed activity inhibiting HBsAg secretion; 20 compounds showed activity inhibiting HBeAg secretion; and 25 compounds possessed inhibitory activity against HBV DNA replication according to our anti-HBV assay on HepG 2.2.15 cell line in vitro. The most active compound 12 could inhibit not only the secretions of HBsAg and HBeAg, but also HBV DNA replication with IC50 values of 15.02 mu M (SI = 111.3), 9.00 mu M (SI = 185.9) and 12.01 mu M (SI = 139.2). (C) 2014 Elsevier B.V. All rights reserved.
关键词Polyacetylenes Anti-hbv Activity Artemisia Capillaris
资助信息National Natural Science Foundation of China [81202436];National Science Foundation of China for Distinguished Young Scholars [81025023];Youth Innovation Promotion Association, CAS
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2014.03.017
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000336819400026
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18203
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.; chenjj@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhao, Yong,Geng, Chang-An,Sun, Chang-Li,et al. Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris[J]. FITOTERAPIA,2014,95:187-193.
APA Zhao, Yong.,Geng, Chang-An.,Sun, Chang-Li.,Ma, Yun-Bao.,Huang, Xiao-Yan.,...&chenjj@mail.kib.ac.cn.(2014).Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris.FITOTERAPIA,95,187-193.
MLA Zhao, Yong,et al."Polyacetylenes and anti-hepatitis B virus active constituents from Artemisia capillaris".FITOTERAPIA 95(2014):187-193.
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