| Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia | |
Zhao, Gao-Ting1; Liu, Jie-Qing2; Deng, Yuan-Yuan2,3; Li, Hai-Zhou1; Chen, Jian-Chao2; Zhang, Zhi-Run2; Zhou, Lin2; Qiu, Ming-Hua2,3 ; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; mhchiu@mail.kib.ac.cn
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| 2014-06-01 | |
| 发表期刊 | FITOTERAPIA
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| ISSN | 0367-326X |
| 卷号 | 95页码:75-82 |
| 摘要 | Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5 beta,19-epoxy-25-methoxycucurbita-6,23-diene-3 beta,19-diol (7), 5 beta,19-epoxycucurbita-6, 23-diene-3 beta,19,25-triol (8), kuguacin R (9), and (19R,23E)-5 beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3 beta-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC50 values of 143-20.5 mol/L. (C) 2014 Elsevier B.V. All rights reserved. |
| 关键词 | Momordica Charantia Cucurbitaceae Cucurbitane-type Triterpenoids Cytotoxicity |
| 学科领域 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1016/j.fitote.2014.03.005 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000336819400010 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18202 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; mhchiu@mail.kib.ac.cn |
| 作者单位 | 1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Gao-Ting,Liu, Jie-Qing,Deng, Yuan-Yuan,et al. Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia[J]. FITOTERAPIA,2014,95:75-82. |
| APA | Zhao, Gao-Ting.,Liu, Jie-Qing.,Deng, Yuan-Yuan.,Li, Hai-Zhou.,Chen, Jian-Chao.,...&mhchiu@mail.kib.ac.cn.(2014).Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia.FITOTERAPIA,95,75-82. |
| MLA | Zhao, Gao-Ting,et al."Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia".FITOTERAPIA 95(2014):75-82. |
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