Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia
Zhao, Gao-Ting1; Liu, Jie-Qing2; Deng, Yuan-Yuan2,3; Li, Hai-Zhou1; Chen, Jian-Chao2; Zhang, Zhi-Run2; Zhou, Lin2; Qiu, Ming-Hua2,3; Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; mhchiu@mail.kib.ac.cn
2014-06-01
Source PublicationFITOTERAPIA
ISSN0367-326X
Volume95Pages:75-82
AbstractSix new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5 beta,19-epoxy-25-methoxycucurbita-6,23-diene-3 beta,19-diol (7), 5 beta,19-epoxycucurbita-6, 23-diene-3 beta,19,25-triol (8), kuguacin R (9), and (19R,23E)-5 beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3 beta-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC50 values of 143-20.5 mol/L. (C) 2014 Elsevier B.V. All rights reserved.
KeywordMomordica Charantia Cucurbitaceae Cucurbitane-type Triterpenoids Cytotoxicity
Subject AreaChemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1016/j.fitote.2014.03.005
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000336819400010
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18202
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorQiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; mhchiu@mail.kib.ac.cn
Affiliation1.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Gao-Ting,Liu, Jie-Qing,Deng, Yuan-Yuan,et al. Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia[J]. FITOTERAPIA,2014,95:75-82.
APA Zhao, Gao-Ting.,Liu, Jie-Qing.,Deng, Yuan-Yuan.,Li, Hai-Zhou.,Chen, Jian-Chao.,...&mhchiu@mail.kib.ac.cn.(2014).Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia.FITOTERAPIA,95,75-82.
MLA Zhao, Gao-Ting,et al."Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia".FITOTERAPIA 95(2014):75-82.
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