| Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum | |
Yin, Xia1,2; Feng, Tao1; Shang, Jian-Hua1; Zhao, Yun-Li1; Wang, Fang1; Li, Zheng-Hui1; Dong, Ze-Jun1 ; Luo, Xiao-Dong1; Liu, Ji-Kai1; Liu,JK (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China.; jkliu@mail.kib.ac.cn
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| 2014-06-02 | |
| 发表期刊 | CHEMISTRY-A EUROPEAN JOURNAL
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| ISSN | 0947-6539 |
| 卷号 | 20期号:23页码:7001-7009 |
| 摘要 | The established tradition of consuming and marketing wild mushrooms has focused attention on mycotoxicity, which has become a global issue. In the present study, we describe the toxins found in a previously unknown poisonous European mushroom Tricholoma terreum. Fifteen new triterpenoids terreolidesA-F (1-6) and saponaceolidesH-P (8-16) were isolated from the fruiting bodies of the toxic mushroom T. terreum. TerreolidesA-C (1-3) possessed a unique 5/6/7 trioxaspiroketal system, whereas terreolides D-F (4-6) possessed an unprecedented carbon skeleton. Two abundant compounds in the mushroom, saponaceolideB (7) and saponaceolideM (13), displayed acute toxicity, with LD50 values of 88.3 and 63.7mgkg-1 when administered orally in mice. Both compounds were found to increase serum creatine kinase levels in mice, indicating that T. terreum may be the cause of mushroom poisoning ultimately leading to rhabdomyolysis. |
| 关键词 | Enzymes Natural Products Nmr Spectroscopy Structure Elucidation X-ray Diffraction |
| DOI | 10.1002/chem.201400226 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000337574800023 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18199 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Liu,JK (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China.; jkliu@mail.kib.ac.cn |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Xia,Feng, Tao,Shang, Jian-Hua,et al. Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(23):7001-7009. |
| APA | Yin, Xia.,Feng, Tao.,Shang, Jian-Hua.,Zhao, Yun-Li.,Wang, Fang.,...&jkliu@mail.kib.ac.cn.(2014).Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum.CHEMISTRY-A EUROPEAN JOURNAL,20(23),7001-7009. |
| MLA | Yin, Xia,et al."Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum".CHEMISTRY-A EUROPEAN JOURNAL 20.23(2014):7001-7009. |
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