Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum
Yin, Xia1,2; Feng, Tao1; Shang, Jian-Hua1; Zhao, Yun-Li1; Wang, Fang1; Li, Zheng-Hui1; Dong, Ze-Jun1; Luo, Xiao-Dong1; Liu, Ji-Kai1; Liu,JK (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China.; jkliu@mail.kib.ac.cn
2014-06-02
Source PublicationCHEMISTRY-A EUROPEAN JOURNAL
ISSN0947-6539
Volume20Issue:23Pages:7001-7009
AbstractThe established tradition of consuming and marketing wild mushrooms has focused attention on mycotoxicity, which has become a global issue. In the present study, we describe the toxins found in a previously unknown poisonous European mushroom Tricholoma terreum. Fifteen new triterpenoids terreolidesA-F (1-6) and saponaceolidesH-P (8-16) were isolated from the fruiting bodies of the toxic mushroom T. terreum. TerreolidesA-C (1-3) possessed a unique 5/6/7 trioxaspiroketal system, whereas terreolides D-F (4-6) possessed an unprecedented carbon skeleton. Two abundant compounds in the mushroom, saponaceolideB (7) and saponaceolideM (13), displayed acute toxicity, with LD50 values of 88.3 and 63.7mgkg-1 when administered orally in mice. Both compounds were found to increase serum creatine kinase levels in mice, indicating that T. terreum may be the cause of mushroom poisoning ultimately leading to rhabdomyolysis.
KeywordEnzymes Natural Products Nmr Spectroscopy Structure Elucidation X-ray Diffraction
DOI10.1002/chem.201400226
Indexed BySCI ; IC
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000337574800023
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/18199
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLiu,JK (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China.; jkliu@mail.kib.ac.cn
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yin, Xia,Feng, Tao,Shang, Jian-Hua,et al. Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(23):7001-7009.
APA Yin, Xia.,Feng, Tao.,Shang, Jian-Hua.,Zhao, Yun-Li.,Wang, Fang.,...&jkliu@mail.kib.ac.cn.(2014).Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum.CHEMISTRY-A EUROPEAN JOURNAL,20(23),7001-7009.
MLA Yin, Xia,et al."Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum".CHEMISTRY-A EUROPEAN JOURNAL 20.23(2014):7001-7009.
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