Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum
Yin, Xia1,2; Feng, Tao1; Shang, Jian-Hua1; Zhao, Yun-Li1; Wang, Fang1; Li, Zheng-Hui1; Dong, Ze-Jun1; Luo, Xiao-Dong1; Liu, Ji-Kai1; Liu,JK (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China.; jkliu@mail.kib.ac.cn
2014-06-02
发表期刊CHEMISTRY-A EUROPEAN JOURNAL
ISSN0947-6539
卷号20期号:23页码:7001-7009
摘要The established tradition of consuming and marketing wild mushrooms has focused attention on mycotoxicity, which has become a global issue. In the present study, we describe the toxins found in a previously unknown poisonous European mushroom Tricholoma terreum. Fifteen new triterpenoids terreolidesA-F (1-6) and saponaceolidesH-P (8-16) were isolated from the fruiting bodies of the toxic mushroom T. terreum. TerreolidesA-C (1-3) possessed a unique 5/6/7 trioxaspiroketal system, whereas terreolides D-F (4-6) possessed an unprecedented carbon skeleton. Two abundant compounds in the mushroom, saponaceolideB (7) and saponaceolideM (13), displayed acute toxicity, with LD50 values of 88.3 and 63.7mgkg-1 when administered orally in mice. Both compounds were found to increase serum creatine kinase levels in mice, indicating that T. terreum may be the cause of mushroom poisoning ultimately leading to rhabdomyolysis.
关键词Enzymes Natural Products Nmr Spectroscopy Structure Elucidation X-ray Diffraction
资助信息National Natural Sciences Foundation of China [81373289, U1132607, 81102346]
DOI10.1002/chem.201400226
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000337574800023
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18199
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Liu,JK (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,Kunming 650201,Peoples R China.; jkliu@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Yin, Xia,Feng, Tao,Shang, Jian-Hua,et al. Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum[J]. CHEMISTRY-A EUROPEAN JOURNAL,2014,20(23):7001-7009.
APA Yin, Xia.,Feng, Tao.,Shang, Jian-Hua.,Zhao, Yun-Li.,Wang, Fang.,...&jkliu@mail.kib.ac.cn.(2014).Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum.CHEMISTRY-A EUROPEAN JOURNAL,20(23),7001-7009.
MLA Yin, Xia,et al."Chemical and Toxicological Investigations of a Previously Unknown Poisonous European Mushroom Tricholoma terreum".CHEMISTRY-A EUROPEAN JOURNAL 20.23(2014):7001-7009.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Yin-2014-Chemical an(936KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yin, Xia]的文章
[Feng, Tao]的文章
[Shang, Jian-Hua]的文章
百度学术
百度学术中相似的文章
[Yin, Xia]的文章
[Feng, Tao]的文章
[Shang, Jian-Hua]的文章
必应学术
必应学术中相似的文章
[Yin, Xia]的文章
[Feng, Tao]的文章
[Shang, Jian-Hua]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。