| Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China | |
Li, Xiao-Lan1; Wu, Chun-Feng2; Wu, Gui-Sheng2 ; Li,XL (reprint author),Kunming Med Coll,Affiliated Yanan Hosp,Dept Dermatol & Rheumatol,Kunming 650051,Yunnan,Peoples R China.; lixiaolan96@hotmail.com; wuguisheng@mail.kib.ac.cn
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| 2014 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF GENOMICS
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| ISSN | 2314-436X |
| 页码 | 870597 |
| 摘要 | Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors. The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis. In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age-and sex-matched control subjects were enrolled. Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects. We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs:IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups. Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population. The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27-0.96) in Chinese. Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R. Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population. |
| 关键词 | Genome-wide Scan Interleukin-15 Gene Susceptibility Loci Onset Psoriasis Polymorphisms Association Population Linkage |
| 学科领域 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| DOI | 10.1155/2014/870597 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337449200001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18189 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li,XL (reprint author),Kunming Med Coll,Affiliated Yanan Hosp,Dept Dermatol & Rheumatol,Kunming 650051,Yunnan,Peoples R China.; lixiaolan96@hotmail.com; wuguisheng@mail.kib.ac.cn |
| 作者单位 | 1.Kunming Med Coll, Affiliated Yanan Hosp, Dept Dermatol & Rheumatol, Kunming 650051, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiao-Lan,Wu, Chun-Feng,Wu, Gui-Sheng,et al. Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China[J]. INTERNATIONAL JOURNAL OF GENOMICS,2014:870597. |
| APA | Li, Xiao-Lan,Wu, Chun-Feng,Wu, Gui-Sheng,Li,XL ,lixiaolan96@hotmail.com,&wuguisheng@mail.kib.ac.cn.(2014).Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China.INTERNATIONAL JOURNAL OF GENOMICS,870597. |
| MLA | Li, Xiao-Lan,et al."Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China".INTERNATIONAL JOURNAL OF GENOMICS (2014):870597. |
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