中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 植物化学与西部植物资源持续利用国家重点实验室  > 期刊论文
题名: Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China
作者: Li, Xiao-Lan1; Wu, Chun-Feng2; Wu, Gui-Sheng2
刊名: INTERNATIONAL JOURNAL OF GENOMICS
关键词: GENOME-WIDE SCAN ; INTERLEUKIN-15 GENE ; SUSCEPTIBILITY LOCI ; ONSET PSORIASIS ; POLYMORPHISMS ; ASSOCIATION ; POPULATION ; LINKAGE
英文摘要: Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors. The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis. In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age-and sex-matched control subjects were enrolled. Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects. We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs:IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups. Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population. The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27-0.96) in Chinese. Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R. Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population.
出版日期: 2014
页码: 870597
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
ISSN号: 2314-436X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18189
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Li-2014-Genetic Variations o.pdf(1141KB)----开放获取View Download

作者单位: 1.Kunming Med Coll, Affiliated Yanan Hosp, Dept Dermatol & Rheumatol, Kunming 650051, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

Recommended Citation:
Li,Xiao-Lan;Wu,Chun-Feng;Wu,Gui-Sheng.Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China,INTERNATIONAL JOURNAL OF GENOMICS,2014,():870597
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Xiao-Lan]'s Articles
[Wu, Chun-Feng]'s Articles
[Wu, Gui-Sheng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Xiao-Lan]‘s Articles
[Wu, Chun-Feng]‘s Articles
[Wu, Gui-Sheng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Li-2014-Genetic Variations o.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace