Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China
Li, Xiao-Lan1; Wu, Chun-Feng2; Wu, Gui-Sheng2; Li,XL (reprint author),Kunming Med Coll,Affiliated Yanan Hosp,Dept Dermatol & Rheumatol,Kunming 650051,Yunnan,Peoples R China.; lixiaolan96@hotmail.com; wuguisheng@mail.kib.ac.cn
2014
发表期刊INTERNATIONAL JOURNAL OF GENOMICS
ISSN2314-436X
页码870597
摘要Psoriasis is a chronic inflammatory and hyperproliferative skin disease affected by both genetic and environmental factors. The aim of the present study was to investigate polymorphisms in a candidate gene family of interleukin (IL) in unrelated Chinese patients with psoriasis and control subjects without psoriasis. In this case-control study, 200 unrelated Chinese psoriasis patients and 298 age-and sex-matched control subjects were enrolled. Genomic DNA was prepared from peripheral blood obtained from all psoriasis patients and control subjects. We genotyped seven single-nucleotide polymorphisms (SNPs) in candidate genes of six ILs:IL4, IL10, IL12B, IL13, IL15, and IL23R, which have been shown in the literature to be associated with psoriasis in other ethnic groups. Among the seven SNPs in the six IL genes studied, only the rs3212227 in the IL12B gene was found to be associated with psoriasis at genotypic level in the studied population. The C/C genotype in the IL12B gene is a protective factor of psoriasis (P = 0.0218; OR = 0.51; 95% CI: 0.27-0.96) in Chinese. Furthermore, the studied Chinese population has extremely low minor allele frequency for IL23R. Together, the data reveal unique genetic patterns in Chinese that may be in part responsible for the lower risk for psoriasis in this population.
关键词Genome-wide Scan Interleukin-15 Gene Susceptibility Loci Onset Psoriasis Polymorphisms Association Population Linkage
资助信息National Natural Science Foundation of China [81360457];Natural Science Foundation of Yunnan Province [2012FB099]
学科领域Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
DOI10.1155/2014/870597
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号WOS:000337449200001
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18189
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li,XL (reprint author),Kunming Med Coll,Affiliated Yanan Hosp,Dept Dermatol & Rheumatol,Kunming 650051,Yunnan,Peoples R China.; lixiaolan96@hotmail.com; wuguisheng@mail.kib.ac.cn
作者单位1.Kunming Med Coll, Affiliated Yanan Hosp, Dept Dermatol & Rheumatol, Kunming 650051, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Li, Xiao-Lan,Wu, Chun-Feng,Wu, Gui-Sheng,et al. Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China[J]. INTERNATIONAL JOURNAL OF GENOMICS,2014:870597.
APA Li, Xiao-Lan,Wu, Chun-Feng,Wu, Gui-Sheng,Li,XL ,lixiaolan96@hotmail.com,&wuguisheng@mail.kib.ac.cn.(2014).Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China.INTERNATIONAL JOURNAL OF GENOMICS,870597.
MLA Li, Xiao-Lan,et al."Genetic Variations of Cytokines and Cytokine Receptors in Psoriasis Patients from China".INTERNATIONAL JOURNAL OF GENOMICS (2014):870597.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Li-2014-Genetic Vari(1141KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Xiao-Lan]的文章
[Wu, Chun-Feng]的文章
[Wu, Gui-Sheng]的文章
百度学术
百度学术中相似的文章
[Li, Xiao-Lan]的文章
[Wu, Chun-Feng]的文章
[Wu, Gui-Sheng]的文章
必应学术
必应学术中相似的文章
[Li, Xiao-Lan]的文章
[Wu, Chun-Feng]的文章
[Wu, Gui-Sheng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。