Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A

doi:10.1021/ol501287x

	Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A
	Deng, Xu1 ; Liang, Kangjiang 1,2; Tong, Xiaogang 1,2; Ding, Ming 1,2; Li, Dashan 1,2; Xia, Chengfeng 1; Xia,CF (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; xiachengfeng@mail.kib.ac.cn
	2014-06-20
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	16 期号:12 页码:3276-3279
摘要	An unprecedented copper-catalyzed intramolecular radical cyclization was developed for the synthesis of 3-hydroxypyrroloindoline skeletons in excellent yields. The 3-hydroxyl group was introduced by trapping the radical intermediate with molecular oxygen or TEMPO. This process represents a unique radical oxidation pathway for tryptamine/tryptophan derivatives and allows a rapid biomimetic synthesis of natural product protubonine A.
关键词	Physicochemical Properties Tryptophan Derivatives Gypsetin Configuration Fermentation Inhibitor Chemistry Discovery Indoles Nw-g01
学科领域	Chemistry, Organic
DOI	10.1021/ol501287x
收录类别	SCI ; IC ; CCR
语种	英语
WOS记录号	WOS:000337869800027
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18182
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Xia,CF (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China.; xiachengfeng@mail.kib.ac.cn
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Deng, Xu,Liang, Kangjiang,Tong, Xiaogang,et al. Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A[J]. ORGANIC LETTERS,2014,16(12):3276-3279.
APA	Deng, Xu.,Liang, Kangjiang.,Tong, Xiaogang.,Ding, Ming.,Li, Dashan.,...&xiachengfeng@mail.kib.ac.cn.(2014).Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A.ORGANIC LETTERS,16(12),3276-3279.
MLA	Deng, Xu,et al."Copper-Catalyzed Radical Cyclization To Access 3-Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A".ORGANIC LETTERS 16.12(2014):3276-3279.

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