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题名: Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
作者: Wang, Jianjun1; Li, Ping1; Li, Baosai2; Guo, Zhiyong1; Kennelly, Edward J.1, 3, 4; Long, Chunlin1, 5
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
关键词: HIV-1 REVERSE-TRANSCRIPTASE ; PHOSPHODIESTERASE 10A INHIBITORS ; GLUTAMATE RACEMASE ; DRUG DESIGN ; DIHYDROFOLATE-REDUCTASE ; THYMIDYLATE SYNTHASE ; PEPTIDE DEFORMYLASE ; CELL-DIVISION ; IN-VITRO ; TARGET
英文摘要: Elephantopus scaber is an ethnomedicinal plant used by the Zhuang people in Southwest China to treat headaches, colds, diarrhea, hepatitis, and bronchitis. A new delta-truxinate derivative, ethyl, methyl 3,4,3',4'-tetrahydroxy-delta-truxinate (1), was isolated from the ethyl acetate extract of the entire plant, along with 4 known compounds. The antioxidant activity of these 5 compounds was determined by ABTS radical scavenging assay. Compound 1 was also tested for its cytotoxicity effect against HepG2 by MTT assay (IC50 = 60 mu M), and its potential anti-inflammatory, antibiotic, and antitumor bioactivities were predicted using target fishing method software.
出版日期: 2014
页码: 569594
语种: 英语
收录类别: SCI
学科分类: Integrative & Complementary Medicine
ISSN号: 1741-427X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18153
Appears in Collections:资源植物与生物技术所级重点实验室_期刊论文

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作者单位: 1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
2.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China
3.CUNY Herbert H Lehman Coll, Dept Biol Sci, Bronx, NY 10468 USA
4.CUNY, Grad Ctr, Bronx, NY 10468 USA
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China

Recommended Citation:
Wang,Jianjun;Li,Ping;Li,Baosai;Guo,Zhiyong;Kennelly,EdwardJ.;Long,Chunlin.Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China,EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,():569594
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