Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
Wang, Jianjun1; Li, Ping1; Li, Baosai2; Guo, Zhiyong1; Kennelly, Edward J.1,3,4; Long, Chunlin1,5; Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,27 Zhong Guan Cun South Ave,Beijing 100081,Peoples R China.; long@mail.kib.ac.cn
2014
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
页码569594
摘要Elephantopus scaber is an ethnomedicinal plant used by the Zhuang people in Southwest China to treat headaches, colds, diarrhea, hepatitis, and bronchitis. A new delta-truxinate derivative, ethyl, methyl 3,4,3',4'-tetrahydroxy-delta-truxinate (1), was isolated from the ethyl acetate extract of the entire plant, along with 4 known compounds. The antioxidant activity of these 5 compounds was determined by ABTS radical scavenging assay. Compound 1 was also tested for its cytotoxicity effect against HepG2 by MTT assay (IC50 = 60 mu M), and its potential anti-inflammatory, antibiotic, and antitumor bioactivities were predicted using target fishing method software.
关键词Hiv-1 Reverse-transcriptase Phosphodiesterase 10a Inhibitors Glutamate Racemase Drug Design Dihydrofolate-reductase Thymidylate Synthase Peptide Deformylase Cell-division In-vitro Target
资助信息National Natural Science Foundation of China [31161140345, 31070288]; Ministry of Science & Technology of China [2012FY110300]; Ministry of Education of China [B08044, MUC985-9, MUC98506-01000101]; JSPS Asian Core program [JSPS/AP/109080]
收录类别SCI
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18153
专题资源植物与生物技术所级重点实验室
通讯作者Long,CL (reprint author),Minzu Univ China,Coll Life & Environm Sci,27 Zhong Guan Cun South Ave,Beijing 100081,Peoples R China.; long@mail.kib.ac.cn
作者单位1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China
2.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China
3.CUNY Herbert H Lehman Coll, Dept Biol Sci, Bronx, NY 10468 USA
4.CUNY, Grad Ctr, Bronx, NY 10468 USA
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China
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Wang, Jianjun,Li, Ping,Li, Baosai,et al. Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014:569594.
APA Wang, Jianjun.,Li, Ping.,Li, Baosai.,Guo, Zhiyong.,Kennelly, Edward J..,...&long@mail.kib.ac.cn.(2014).Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,569594.
MLA Wang, Jianjun,et al."Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2014):569594.
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