Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives
Sun, Cheng-Jun1; Chen, Wen1; Li, Yan2; Liu, Lan-Xiang1; Wang, Xue-Quan1; Li, Li-Juan1; Zhang, Hong-Bin1; Yang, Xiao-Dong1
2014
发表期刊RSC ADVANCES
ISSN2046-2069
卷号4期号:31页码:16312-16319
摘要A series of novel 8-substituted 2,3,5,6-tetrahydrobenzo[ 1,2-b:4,5-b'] difuran imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of the 5,6-dimethyl-benzimidazole ring and substitution of the imidazolyl-3-position with a 2-naphthylmethyl or 4-methylbenzyl group were vital for modulating cytotoxic activity. Compound 43 was found to be the most potent derivative and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7), colon carcinoma (SW480), myeloid leukaemia (HL-60) and lung carcinoma (A549) with an IC50 value 65.0-fold, 48.5-fold, 21.2-fold and 19.9-fold more sensitive to DDP, respectively.
关键词Hybrid Compounds Cytotoxic Activities Natural-products Drug Discovery Analogs Dihydrobenzofuran Cycloaddition Benzofurans Iodides Trans
资助信息Changjiang Scholars and Innovative Research Team in University [IRT13095]; Natural Science Foundation of China [21332007, 21062026]; Yunnan Province [2013FA028, 2012FB113, 2010GA014]; Rroject of Recruited Top Talent of Sciences and Technology of Yunnan Province [2009C1120]; 100 Talents Program of CAS
学科领域Chemistry
DOI10.1039/c3ra43183e
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000334681800060
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18131
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
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GB/T 7714
Sun, Cheng-Jun,Chen, Wen,Li, Yan,et al. Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives[J]. RSC ADVANCES,2014,4(31):16312-16319.
APA Sun, Cheng-Jun.,Chen, Wen.,Li, Yan.,Liu, Lan-Xiang.,Wang, Xue-Quan.,...&Yang, Xiao-Dong.(2014).Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives.RSC ADVANCES,4(31),16312-16319.
MLA Sun, Cheng-Jun,et al."Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4, 5-b'] difuran imidazolium salt derivatives".RSC ADVANCES 4.31(2014):16312-16319.
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