| Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear | |
Peng, Xing-Rong1,2; Liu, Jie-Qing1; Wang, Cui-Fang1; Li, Xu-Yang1,2; Shu, Yi1; Zhou, Lin1; Qiu, Ming-Hua1
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| Corresponding Author | Qiu,MH (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; mhchiu@mail.kib.ac.cn |
| 2014-04-01 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| Volume | 77Issue:4Pages:737-743 |
| Abstract | Two novel trinorlanostanes, cochlates A and B (1 and 2), with a 3,4-seco-9,10-seco-9,19-cyclo skeleton, as well as six new triterpenoids, fornicatins D-F (3-5) and ganodercochlearins A-C (6-8), together with five known triterpenoids (9-13), were obtained from the fruiting bodies of Ganoderma cochlear. The structural elucidation was achieved by interpretation of spectroscopic data, and compounds 2 and 7a were further characterized by X-ray crystallographic analysis. Fornicatins A, D, and F (10, 3, and 5) and fredelin (13) lowered the ALT and AST levels in HepG2 cells treated with H2O2, suggesting that they could display in vivo hepatoprotective activities. |
| Keyword | Antitumor-promoting Activity Inonotus-obliquus Sclerotia Mushroom Sinense |
| Subject Area | Plant Sciences ; Pharmacology & Pharmacy |
| DOI | 10.1021/np400323u |
| Indexed By | SCI ; IC |
| Language | 英语 |
| WOS ID | WOS:000335127200001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/18120 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Peng, Xing-Rong,Liu, Jie-Qing,Wang, Cui-Fang,et al. Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):737-743. |
| APA | Peng, Xing-Rong.,Liu, Jie-Qing.,Wang, Cui-Fang.,Li, Xu-Yang.,Shu, Yi.,...&Qiu, Ming-Hua.(2014).Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear.JOURNAL OF NATURAL PRODUCTS,77(4),737-743. |
| MLA | Peng, Xing-Rong,et al."Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear".JOURNAL OF NATURAL PRODUCTS 77.4(2014):737-743. |
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| Peng-2014-Hepatoprot（326KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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