Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear
Peng, Xing-Rong1,2; Liu, Jie-Qing1; Wang, Cui-Fang1; Li, Xu-Yang1,2; Shu, Yi1; Zhou, Lin1; Qiu, Ming-Hua1
2014-04-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号77期号:4页码:737-743
摘要Two novel trinorlanostanes, cochlates A and B (1 and 2), with a 3,4-seco-9,10-seco-9,19-cyclo skeleton, as well as six new triterpenoids, fornicatins D-F (3-5) and ganodercochlearins A-C (6-8), together with five known triterpenoids (9-13), were obtained from the fruiting bodies of Ganoderma cochlear. The structural elucidation was achieved by interpretation of spectroscopic data, and compounds 2 and 7a were further characterized by X-ray crystallographic analysis. Fornicatins A, D, and F (10, 3, and 5) and fredelin (13) lowered the ALT and AST levels in HepG2 cells treated with H2O2, suggesting that they could display in vivo hepatoprotective activities.
关键词Antitumor-promoting Activity Inonotus-obliquus Sclerotia Mushroom Sinense
资助信息General Program of NSFC [81172940]; Knowledge Innovation Program of the CAS [KSCX2-YW-G-038, KSCX2-YW-R-194]; Top Talents Program from the Department of Science and Technology in Yunnan Province [20080A007]; Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ14]
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np400323u
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000335127200001
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18120
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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GB/T 7714
Peng, Xing-Rong,Liu, Jie-Qing,Wang, Cui-Fang,et al. Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(4):737-743.
APA Peng, Xing-Rong.,Liu, Jie-Qing.,Wang, Cui-Fang.,Li, Xu-Yang.,Shu, Yi.,...&Qiu, Ming-Hua.(2014).Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear.JOURNAL OF NATURAL PRODUCTS,77(4),737-743.
MLA Peng, Xing-Rong,et al."Hepatoprotective Effects of Triterpenoids from Ganoderma cochlear".JOURNAL OF NATURAL PRODUCTS 77.4(2014):737-743.
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