| 6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity | |
Jiang, Hua-Yi1,2; Wang, Wei-Guang1; Zhou, Min1,2; Wu, Hai-Yan1,2; Zhan, Rui1; Du, Xue1; Pu, Jian-Xin1 ; Sun, Han-Dong1
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| 通讯作者 | Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 2014-04-01 | |
| 发表期刊 | CHINESE CHEMICAL LETTERS
 |
| ISSN | 1001-8417 |
| 卷号 | 25期号:4页码:541-544 |
| 摘要 | One new 6,7-seco-ent-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of Isodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C (4), and sculponeatin Q (5). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC50 values ranging from 1.8 mu mol/L to 3.31 mu mol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 3.3 mu mol/L. (C) 2014 Jian-Xin Pu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 关键词 | Isodon Sculponeatus Cytotoxicity 6 Anti-inflammatory Activity 7-seco-ent-kaurane Diterpenoid |
| 学科领域 | Chemistry |
| DOI | 10.1016/j.cclet.2014.01.041 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000335108000012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18119 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Hua-Yi,Wang, Wei-Guang,Zhou, Min,et al. 6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity[J]. CHINESE CHEMICAL LETTERS,2014,25(4):541-544. |
| APA | Jiang, Hua-Yi.,Wang, Wei-Guang.,Zhou, Min.,Wu, Hai-Yan.,Zhan, Rui.,...&Sun, Han-Dong.(2014).6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity.CHINESE CHEMICAL LETTERS,25(4),541-544. |
| MLA | Jiang, Hua-Yi,et al."6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity".CHINESE CHEMICAL LETTERS 25.4(2014):541-544. |
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