6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity
Jiang, Hua-Yi1,2; Wang, Wei-Guang1; Zhou, Min1,2; Wu, Hai-Yan1,2; Zhan, Rui1; Du, Xue1; Pu, Jian-Xin1; Sun, Han-Dong1
2014-04-01
发表期刊CHINESE CHEMICAL LETTERS
ISSN1001-8417
卷号25期号:4页码:541-544
摘要One new 6,7-seco-ent-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of Isodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C (4), and sculponeatin Q (5). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC50 values ranging from 1.8 mu mol/L to 3.31 mu mol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 3.3 mu mol/L. (C) 2014 Jian-Xin Pu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
关键词Isodon Sculponeatus Cytotoxicity 6 Anti-inflammatory Activity 7-seco-ent-kaurane Diterpenoid
资助信息National Natural Science Foundation of China [21322204, 81172939]; NSFC-Joint Foundation of Yunnan Province [U1302223]; Reservation-talent Project of Yunnan Province [2011CI043]; West Light Foundation of the Chinese Academy of Sciences
学科领域Chemistry
DOI10.1016/j.cclet.2014.01.041
收录类别SCI
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000335108000012
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18119
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Jiang, Hua-Yi,Wang, Wei-Guang,Zhou, Min,et al. 6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity[J]. CHINESE CHEMICAL LETTERS,2014,25(4):541-544.
APA Jiang, Hua-Yi.,Wang, Wei-Guang.,Zhou, Min.,Wu, Hai-Yan.,Zhan, Rui.,...&Sun, Han-Dong.(2014).6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity.CHINESE CHEMICAL LETTERS,25(4),541-544.
MLA Jiang, Hua-Yi,et al."6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity".CHINESE CHEMICAL LETTERS 25.4(2014):541-544.
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