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题名: 6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity
作者: Jiang, Hua-Yi1, 2; Wang, Wei-Guang1; Zhou, Min1, 2; Wu, Hai-Yan1, 2; Zhan, Rui1; Du, Xue1; Pu, Jian-Xin1; null(孙汉董)1
刊名: CHINESE CHEMICAL LETTERS
关键词: Isodon sculponeatus ; 6,7-seco-ent-Kaurane diterpenoid ; Cytotoxicity ; Anti-inflammatory activity
英文摘要: One new 6,7-seco-ent-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of Isodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C (4), and sculponeatin Q (5). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC50 values ranging from 1.8 mu mol/L to 3.31 mu mol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 value of 3.3 mu mol/L. (C) 2014 Jian-Xin Pu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
出版日期: 2014-04-01
卷号: 25, 期号:4, 页码:541-544
语种: 英语
收录类别: SCI
学科分类: Chemistry
ISSN号: 1001-8417
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18119
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Jiang,Hua-Yi;Wang,Wei-Guang;Zhou,Min;Wu,Hai-Yan;Zhan,Rui;Du,Xue;Pu,Jian-Xin;Sun,Han-Dong.6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity,CHINESE CHEMICAL LETTERS,2014,25(4):541-544
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