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题名: Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells
作者: Ni, Guanghui1, 2; Li, Zhiyuan1; Liang, Kangjiang1, 2; Wu, Ting1, 2; De Libero, Gennaro3; Xia, Chengfeng1
刊名: BIOORGANIC & MEDICINAL CHEMISTRY
关键词: NKT cells ; Antigen ; lysophospholipids ; SAR
英文摘要: Plasmalogen lysophosphatidylethanolamine (pLPE) had been identified as a self antigen for natural killer T cells (NKT cells). It is very important in the development, maturation and activation of NKT cells in thymus. Besides, pLPE is a novel type of antigen for NKT cells. To evaluate the structure-activity relationship (SAR) of this new antigen, pLPE and its analogues referred to different aliphatic chains and linkages at the sn-1 position of the glycerol backbone were synthesized, and the biological activities of these analogues was characterized. It is discovered that the linkages between phosphate and lipid moiety are not important for the antigens' activities. The pLPE analogues 1, 3, 4, 7 and 9, which have additional double bonds on lipid parts, were identified as new NKT agonists. Moreover, the analogues 4, 7 and 9 were discovered as potent Th2 activators for NKT cells. (C) 2014 Elsevier Ltd. All rights reserved.
出版日期: 2014-06-01
卷号: 22, 期号:11, 页码:2966-2973
DOI标识: 10.1016/j.bmc.2014.04.012
语种: 英语
收录类别: SCI ; IC
学科分类: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
ISSN号: 0968-0896
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18117
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland

Recommended Citation:
Ni,Guanghui;Li,Zhiyuan;Liang,Kangjiang;Wu,Ting;DeLibero,Gennaro;Xia,Chengfeng.Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells,BIOORGANIC & MEDICINAL CHEMISTRY,2014,22(11):2966-2973
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