Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells
Ni, Guanghui1,2; Li, Zhiyuan1; Liang, Kangjiang1,2; Wu, Ting1,2; De Libero, Gennaro3; Xia, Chengfeng1
2014-06-01
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY
ISSN0968-0896
卷号22期号:11页码:2966-2973
摘要Plasmalogen lysophosphatidylethanolamine (pLPE) had been identified as a self antigen for natural killer T cells (NKT cells). It is very important in the development, maturation and activation of NKT cells in thymus. Besides, pLPE is a novel type of antigen for NKT cells. To evaluate the structure-activity relationship (SAR) of this new antigen, pLPE and its analogues referred to different aliphatic chains and linkages at the sn-1 position of the glycerol backbone were synthesized, and the biological activities of these analogues was characterized. It is discovered that the linkages between phosphate and lipid moiety are not important for the antigens' activities. The pLPE analogues 1, 3, 4, 7 and 9, which have additional double bonds on lipid parts, were identified as new NKT agonists. Moreover, the analogues 4, 7 and 9 were discovered as potent Th2 activators for NKT cells. (C) 2014 Elsevier Ltd. All rights reserved.
关键词Nkt Cells Antigen Lysophospholipids Sar
资助信息Yunnan High-End Technology Professionals Introduction Program [2010CI117]; National Natural Science Foundation of China [21272242]; National Basic Research Program of China [2011CB915500]
学科领域Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
DOI10.1016/j.bmc.2014.04.012
收录类别SCI ; IC
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS记录号WOS:000335451500006
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18117
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland
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Ni, Guanghui,Li, Zhiyuan,Liang, Kangjiang,et al. Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2014,22(11):2966-2973.
APA Ni, Guanghui,Li, Zhiyuan,Liang, Kangjiang,Wu, Ting,De Libero, Gennaro,&Xia, Chengfeng.(2014).Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells.BIOORGANIC & MEDICINAL CHEMISTRY,22(11),2966-2973.
MLA Ni, Guanghui,et al."Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells".BIOORGANIC & MEDICINAL CHEMISTRY 22.11(2014):2966-2973.
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