| Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells | |
| Ni, Guanghui1,2; Li, Zhiyuan1; Liang, Kangjiang1,2; Wu, Ting1,2; De Libero, Gennaro3; Xia, Chengfeng1 | |
| 通讯作者 | Xia,CF (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; xiachengfeng@mail.kib.ac.cn |
| 2014-06-01 | |
| 发表期刊 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| ISSN | 0968-0896 |
| 卷号 | 22期号:11页码:2966-2973 |
| 摘要 | Plasmalogen lysophosphatidylethanolamine (pLPE) had been identified as a self antigen for natural killer T cells (NKT cells). It is very important in the development, maturation and activation of NKT cells in thymus. Besides, pLPE is a novel type of antigen for NKT cells. To evaluate the structure-activity relationship (SAR) of this new antigen, pLPE and its analogues referred to different aliphatic chains and linkages at the sn-1 position of the glycerol backbone were synthesized, and the biological activities of these analogues was characterized. It is discovered that the linkages between phosphate and lipid moiety are not important for the antigens' activities. The pLPE analogues 1, 3, 4, 7 and 9, which have additional double bonds on lipid parts, were identified as new NKT agonists. Moreover, the analogues 4, 7 and 9 were discovered as potent Th2 activators for NKT cells. (C) 2014 Elsevier Ltd. All rights reserved. |
| 关键词 | Nkt Cells Antigen Lysophospholipids Sar |
| 学科领域 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| DOI | 10.1016/j.bmc.2014.04.012 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000335451500006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18117 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland |
| 推荐引用方式 GB/T 7714 | Ni, Guanghui,Li, Zhiyuan,Liang, Kangjiang,et al. Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2014,22(11):2966-2973. |
| APA | Ni, Guanghui,Li, Zhiyuan,Liang, Kangjiang,Wu, Ting,De Libero, Gennaro,&Xia, Chengfeng.(2014).Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells.BIOORGANIC & MEDICINAL CHEMISTRY,22(11),2966-2973. |
| MLA | Ni, Guanghui,et al."Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells".BIOORGANIC & MEDICINAL CHEMISTRY 22.11(2014):2966-2973. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Ni-2014-Synthesis an（861KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论