Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)

doi:10.1016/j.phytol.2014.01.010

	Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)
	Kopa, Theodora K.1,2; Tchinda, Alembert T.2,3; Tala, Michel F.1,4; Zofou, Denis 5; Jumbam, Ransom 5; Wabo, Hippolyte K.1; Titanji, Vincent P. K.5; Frederich, Michel 3; Tan, Ning-Hua 4; Tane, Pierre 1
通讯作者	Wabo,HK (reprint author),Univ Dschang,Dept Chem,POB 67,Dschang,Cameroon. ; hkamdemw@yahoo.ca ; ptane@yahoo.com
	2014-05-01
发表期刊	PHYTOCHEMISTRY LETTERS
ISSN	1874-3900
卷号	8 页码:41-45
摘要	Chemical investigation of the methanol extract of the leaves of Tectona grandis led to the isolation of one new anthraquinone derivative, grandiquinone A (3-acetoxy-8-hydroxy-2-methylanthraquinone) (1), along with nine known compounds: 5,8-dihydroxy-2-methylanthraquinone (2), hydroxysesamone (3), 3-hydroxy-2-methylanthraquinone (4), quinizarine (5), betulinic acid (6), ursolic acid (7), tectograndone (8), corosolic acid (9) and sitosterol 3-O-b-D-glucopyranoside (10). Compounds 2 and 3 were isolated for the first time from the leaves of this plant, while 5 has never been reported from the genus Tectona. Hydroxysesamone (3) and tectograndone (8) were subjected to cyclisation and acetylation reactions to afford two hemisynthetic derivatives, 6,9-dihydroxy-2,2-(dimethyldihydropyrano)-3,4-dihydro-2Hbenzo[g] chromene-5,10-dione (11) and acetyltectograndone (12) respectively, which are reported here for the first time. The ethyl acetate-soluble portion, some of the isolated compounds and hemisynthetic derivatives were evaluated for their antiplasmodial activity against the multidrug-resistant Dd2 strain of Plasmodium falciparum. Compound 3 showed a prominent activity, while 2, 8, 9, 11 and 12 showed significant in vitro anti-malarial activity. Compound 1 was weakly active in this test. The structures of the compounds were elucidated by spectroscopic methods and comparison of the data with the literature. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
关键词	Verbenaceae Tectona Grandis Anthraquinone Napthoquinone Antiplasmodial Activity
学科领域	Biochemistry & Molecular Biology ; Plant Sciences
DOI	10.1016/j.phytol.2014.01.010
收录类别	SCI
语种	英语
WOS记录号	WOS:000335743300009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/18106
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Univ Dschang, Dept Chem, Dschang, Cameroon 2.Inst Med Res & Med Plants Studies IMPM, Yaounde, Cameroon 3.Univ Liege, Dept Pharm, Lab Pharmacognosy, CIRM, B-4000 Liege, Belgium 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 5.Univ Buea, Biotechnol Unit, Buea, Cameroon
推荐引用方式 GB/T 7714	Kopa, Theodora K.,Tchinda, Alembert T.,Tala, Michel F.,et al. Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)[J]. PHYTOCHEMISTRY LETTERS,2014,8:41-45.
APA	Kopa, Theodora K..,Tchinda, Alembert T..,Tala, Michel F..,Zofou, Denis.,Jumbam, Ransom.,...&Tane, Pierre.(2014).Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae).PHYTOCHEMISTRY LETTERS,8,41-45.
MLA	Kopa, Theodora K.,et al."Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)".PHYTOCHEMISTRY LETTERS 8(2014):41-45.

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