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题名: Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)
作者: Kopa, Theodora K.1, 2; Tchinda, Alembert T.2, 3; Tala, Michel F.1, 4; Zofou, Denis5; Jumbam, Ransom5; Wabo, Hippolyte K.1; Titanji, Vincent P. K.5; Frederich, Michel3; Tan, Ning-Hua4; Tane, Pierre1
刊名: PHYTOCHEMISTRY LETTERS
关键词: Verbenaceae ; Tectona grandis ; Anthraquinone ; Napthoquinone ; Antiplasmodial activity
英文摘要: Chemical investigation of the methanol extract of the leaves of Tectona grandis led to the isolation of one new anthraquinone derivative, grandiquinone A (3-acetoxy-8-hydroxy-2-methylanthraquinone) (1), along with nine known compounds: 5,8-dihydroxy-2-methylanthraquinone (2), hydroxysesamone (3), 3-hydroxy-2-methylanthraquinone (4), quinizarine (5), betulinic acid (6), ursolic acid (7), tectograndone (8), corosolic acid (9) and sitosterol 3-O-b-D-glucopyranoside (10). Compounds 2 and 3 were isolated for the first time from the leaves of this plant, while 5 has never been reported from the genus Tectona. Hydroxysesamone (3) and tectograndone (8) were subjected to cyclisation and acetylation reactions to afford two hemisynthetic derivatives, 6,9-dihydroxy-2,2-(dimethyldihydropyrano)-3,4-dihydro-2Hbenzo[g] chromene-5,10-dione (11) and acetyltectograndone (12) respectively, which are reported here for the first time. The ethyl acetate-soluble portion, some of the isolated compounds and hemisynthetic derivatives were evaluated for their antiplasmodial activity against the multidrug-resistant Dd2 strain of Plasmodium falciparum. Compound 3 showed a prominent activity, while 2, 8, 9, 11 and 12 showed significant in vitro anti-malarial activity. Compound 1 was weakly active in this test. The structures of the compounds were elucidated by spectroscopic methods and comparison of the data with the literature. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
出版日期: 2014-05-01
卷号: 8, 页码:41-45
语种: 英语
收录类别: SCI
学科分类: Biochemistry & Molecular Biology ; Plant Sciences
ISSN号: 1874-3900
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18106
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Univ Dschang, Dept Chem, Dschang, Cameroon
2.Inst Med Res & Med Plants Studies IMPM, Yaounde, Cameroon
3.Univ Liege, Dept Pharm, Lab Pharmacognosy, CIRM, B-4000 Liege, Belgium
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
5.Univ Buea, Biotechnol Unit, Buea, Cameroon

Recommended Citation:
Kopa,TheodoraK.;Tchinda,AlembertT.;Tala,MichelF.;Zofou,Denis;Jumbam,Ransom;Wabo,HippolyteK.;Titanji,VincentP.K.;Frederich,Michel;Tan,Ning-Hua;Tane,Pierre.Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae),PHYTOCHEMISTRY LETTERS,2014,8():41-45
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