6(1)-O-Caffeoylarbutin inhibits melanogenesis in zebrafish
Xu, Min1; Lao, Qiao-Cong2; Zhao, Ping3; Zhu, Xiao-Yu2; Zhu, Hong-Tao1; Luo, Xu-Lu3; Yang, Chong-Ren1; He, Jian-Hui2; Li, Chun-Qi2,4; Zhang, Ying-Jun1
2014-06-18
发表期刊NATURAL PRODUCT RESEARCH
ISSN1478-6419
卷号28期号:12页码:932-934
摘要6-O-Caffeoylarbutin, an arbutin derivative, is a naturally occurring glucoside of hydroquinone from Vaccinium dunalianum. On anti-melanogenic effect assay, 6-O-caffeoylarbutin expressed a stronger anti-melanin activity in a dose-dependent manner with about a two-fold more than that of arbutin, but with less toxicity about a two-fold lower than that of arbutin. In addition, melanin synthesis could be fully recovered after the removal of 6-O-caffeoylarbutin. The result suggested that 6-O-caffeoylarbutin could be a candidate natural product to serve as a skin-whitening ingredient with the merits of potent melanin inhibition, less toxicity and reversible melanin synthesis after stopping use.
关键词6-o-caffeoylarbutin Anti-melanogenic Vaccinium Dunalianum
资助信息NSFC [21062018]; 973 Program of Science and Technology of the People's Republic of China [2011CB915503]; Fourteenth Batch Candidates of the Young Academic Leaders of Yunnan Province [2011CI044]; West Light Foundation of the Chinese Academy of Sciences; Scientific Research Foundation (SRF) for the Returned Overseas Chinese Scholars (ROCS), State Education Ministry (SEM)
学科领域Chemistry ; Pharmacology & Pharmacy
DOI10.1080/14786419.2014.883395
收录类别SCI
语种英语
WOS研究方向Chemistry ; Pharmacology & Pharmacy
WOS类目Chemistry, Applied ; Chemistry, Medicinal
WOS记录号WOS:000335848500014
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18101
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Hunter Biotechnol Inc, Transfarland, Xiaoshan Econ & Technol Dev Zone, Hangzhou 311231, Zhejiang, Peoples R China
3.Southwest Forestry Univ, Key Lab Forest Resources Conservat & Use Southwes, Minist Educ, Kunming 650224, Peoples R China
4.Wenzhou Med Univ, Zhejiang Prov Key Lab Technol & Applicat Model Or, Wenzhou 325035, Zhejiang, Peoples R China
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Xu, Min,Lao, Qiao-Cong,Zhao, Ping,et al. 6(1)-O-Caffeoylarbutin inhibits melanogenesis in zebrafish[J]. NATURAL PRODUCT RESEARCH,2014,28(12):932-934.
APA Xu, Min.,Lao, Qiao-Cong.,Zhao, Ping.,Zhu, Xiao-Yu.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2014).6(1)-O-Caffeoylarbutin inhibits melanogenesis in zebrafish.NATURAL PRODUCT RESEARCH,28(12),932-934.
MLA Xu, Min,et al."6(1)-O-Caffeoylarbutin inhibits melanogenesis in zebrafish".NATURAL PRODUCT RESEARCH 28.12(2014):932-934.
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